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- W1486894069 endingPage "162" @default.
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- W1486894069 abstract "The raft theory, the role of cholesterol in the formation of rafts and the function of rafts in signaling and membrane transport, has found wide support in an incredibly diverse array of cellular systems. However, these studies are largely limited to cultured cells in vitro and there has been no systematic genetic analysis. Given the complexities of lipid synthesis and the study of lipids in vivo, this is not surprising. This chapter describes the hereditary disorders that provide unique systems for genetic manipulation of rafts and a potential opportunity to disrupt raft-dependent signaling in the whole animal. Moreover, these diseases and their mouse models provide a more detailed analysis of the wider roles of cholesterol in signaling and the relationships between signaling and membrane trafficking. In particular, an increased understanding of neuronal cholesterol homeostasis and vesicular transport provided by Niemann-Pick Type C (NPC) disease will be important for understanding β-amyloid precursor protein processing in Alzheimer disease that appears to be linked to both cellular cholesterol homeostasis and raft-rich intracellular compartments." @default.
- W1486894069 created "2016-06-24" @default.
- W1486894069 creator A5067631894 @default.
- W1486894069 date "2003-01-01" @default.
- W1486894069 modified "2023-10-16" @default.
- W1486894069 title "Cellular cholesterol, membrane signaling, and disease" @default.
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