Matches in SemOpenAlex for { <https://semopenalex.org/work/W1486894501> ?p ?o ?g. }
- W1486894501 endingPage "279" @default.
- W1486894501 startingPage "245" @default.
- W1486894501 abstract "Programmed cell death (PCD) plays a pivotal role in the development, in the maintenance of homeostasis within multicellular organisms, and mutations in genes known to control PCD have been associated with pathologies, such as cancer, autoimmunity, and neurodegenerative disorders. A family of critical cell death regulators known as the Bcl-2 family is described along with some of the most recent advances in the understanding of their properties, structure, and function. Although apoptosis is a complex process, the available data suggest that Bcl-2 family members regulate a focal point, where a motley of upstream apoptotic signals first converge, and may regulate caspase activation by preventing alterations in mitochondrial homeostasis that would otherwise lead to the release of mitochondrial proteins that are capable of activating downstream caspases. The formation of ion channels by Bcl-2 family members may be one mechanism by which these proteins control mitochondrial processes. In addition to the multitude of proteins that are associated with Bcl-2 family members, many other interesting proteins, such as Raf-1 can also associate and, in some cases, influence the cell survival. Future studies are needed to test the importance of the biochemical activities identified for members of the Bcl-2 family, to determine the relative importance of the interactions between Bcl-2 family members and the proteins they interact with, and how these protein interactions regulate function." @default.
- W1486894501 created "2016-06-24" @default.
- W1486894501 creator A5017727578 @default.
- W1486894501 creator A5018068596 @default.
- W1486894501 creator A5021865796 @default.
- W1486894501 creator A5053752263 @default.
- W1486894501 date "1998-01-01" @default.
- W1486894501 modified "2023-10-18" @default.
- W1486894501 title "Recent Progress on the Regulation of Apoptosis by Bcl-2 Family Members" @default.
- W1486894501 cites W103053889 @default.
- W1486894501 cites W1470758466 @default.
- W1486894501 cites W1520985931 @default.
- W1486894501 cites W1575937211 @default.
- W1486894501 cites W1598082435 @default.
- W1486894501 cites W1598719623 @default.
- W1486894501 cites W1598875578 @default.
- W1486894501 cites W1624001120 @default.
- W1486894501 cites W1628370182 @default.
- W1486894501 cites W1836338391 @default.
- W1486894501 cites W1860582510 @default.
- W1486894501 cites W1963773907 @default.
- W1486894501 cites W1964977785 @default.
- W1486894501 cites W1965217295 @default.
- W1486894501 cites W1969331809 @default.
- W1486894501 cites W1969374202 @default.
- W1486894501 cites W1974189780 @default.
- W1486894501 cites W1976226379 @default.
- W1486894501 cites W1976312800 @default.
- W1486894501 cites W1977707442 @default.
- W1486894501 cites W1979995768 @default.
- W1486894501 cites W1981056903 @default.
- W1486894501 cites W1987785848 @default.
- W1486894501 cites W1989134194 @default.
- W1486894501 cites W1991865867 @default.
- W1486894501 cites W1994068418 @default.
- W1486894501 cites W1994811047 @default.
- W1486894501 cites W1995891719 @default.
- W1486894501 cites W1997208169 @default.
- W1486894501 cites W1998595310 @default.
- W1486894501 cites W1999197294 @default.
- W1486894501 cites W1999761234 @default.
- W1486894501 cites W2000894919 @default.
- W1486894501 cites W2003301112 @default.
- W1486894501 cites W2003756602 @default.
- W1486894501 cites W2004487226 @default.
- W1486894501 cites W2006897943 @default.
- W1486894501 cites W2008348103 @default.
- W1486894501 cites W2009424100 @default.
- W1486894501 cites W2010298858 @default.
- W1486894501 cites W2011272696 @default.
- W1486894501 cites W2019572526 @default.
- W1486894501 cites W2024232113 @default.
- W1486894501 cites W2024582476 @default.
- W1486894501 cites W2025818427 @default.
- W1486894501 cites W2027039228 @default.
- W1486894501 cites W2028703351 @default.
- W1486894501 cites W2030573603 @default.
- W1486894501 cites W2031418665 @default.
- W1486894501 cites W2032221839 @default.
- W1486894501 cites W2032417513 @default.
- W1486894501 cites W2033801757 @default.
- W1486894501 cites W2033847504 @default.
- W1486894501 cites W2033873142 @default.
- W1486894501 cites W2034815057 @default.
- W1486894501 cites W2036274324 @default.
- W1486894501 cites W2037473273 @default.
- W1486894501 cites W2037665471 @default.
- W1486894501 cites W2037758170 @default.
- W1486894501 cites W2038768123 @default.
- W1486894501 cites W2039355845 @default.
- W1486894501 cites W2044512941 @default.
- W1486894501 cites W2045309540 @default.
- W1486894501 cites W2046008863 @default.
- W1486894501 cites W2048573897 @default.
- W1486894501 cites W2048750043 @default.
- W1486894501 cites W2049886823 @default.
- W1486894501 cites W2051070266 @default.
- W1486894501 cites W2051219590 @default.
- W1486894501 cites W2052452850 @default.
- W1486894501 cites W2052853635 @default.
- W1486894501 cites W2054669186 @default.
- W1486894501 cites W2056019276 @default.
- W1486894501 cites W2057257609 @default.
- W1486894501 cites W2057315090 @default.
- W1486894501 cites W2057713336 @default.
- W1486894501 cites W2059666350 @default.
- W1486894501 cites W2062884465 @default.
- W1486894501 cites W2063176993 @default.
- W1486894501 cites W2063385957 @default.
- W1486894501 cites W2068240610 @default.
- W1486894501 cites W2068637026 @default.
- W1486894501 cites W2068807148 @default.
- W1486894501 cites W2070862399 @default.
- W1486894501 cites W2072140726 @default.
- W1486894501 cites W2072143466 @default.
- W1486894501 cites W2072894284 @default.
- W1486894501 cites W2075576299 @default.
- W1486894501 cites W2076310395 @default.