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• W1486908736 abstract "Ovarian cancer is a deadly disease that kills an estimated 15,000 women annually in the United States. It is estimated that approximately 10% of ovarian cancers are due to familial inheritance. The most commonly mutated genes in familial ovarian cancer are BRCA1 and BRCA2. It has been reported that cells carrying the BRCA1 185delAG mutation undergo an enhanced caspase-3 mediated apoptotic response. Here, we report on the transfection of cDNA coding for the putative truncated protein product of the BRCA1 185delAG mutant gene into BRCA1 wild-type human immortalized ovarian surface epithelial (IOSE) cells and ovarian cancer cells. Cells transfected with the BRCA1 185delAG truncation protein (BRAt) showed increased levels of active caspase 3, increased cleavage of caspase 3 substrates, PARP and DFF45, and decreased XIAP and cIAP1 following staurosporine (STS) treatment. BRAt also reduced Akt phosphorylation and over expression of activated Akt in BRAt cells restored caspase-3 activity to that seen in wild type cells. Further, BRAt expression increased" @default.
• W1486908736 created "2016-06-24" @default.
• W1486908736 creator A5027437212 @default.
• W1486908736 date "2008-01-01" @default.
• W1486908736 modified "2023-09-27" @default.
• W1486908736 title "BRCA1 185delAG Mutant Protein, BRAt, Amplifies Caspase-Mediated Apoptosis and Maspin Expression in Ovarian Cells" @default.
• W1486908736 cites W121553317 @default.
• W1486908736 cites W140268124 @default.
• W1486908736 cites W1502713173 @default.
• W1486908736 cites W1513512556 @default.
• W1486908736 cites W1522031609 @default.
• W1486908736 cites W1529693712 @default.
• W1486908736 cites W1535874622 @default.
• W1486908736 cites W1549738923 @default.
• W1486908736 cites W1558788767 @default.
• W1486908736 cites W1571406835 @default.
• W1486908736 cites W1579641819 @default.
• W1486908736 cites W1622753180 @default.
• W1486908736 cites W1688621929 @default.
• W1486908736 cites W1761773172 @default.
• W1486908736 cites W1826136795 @default.
• W1486908736 cites W1902704112 @default.
• W1486908736 cites W1927868261 @default.
• W1486908736 cites W1934253652 @default.
• W1486908736 cites W1940741214 @default.
• W1486908736 cites W1961928411 @default.
• W1486908736 cites W1963592300 @default.
• W1486908736 cites W1964483580 @default.
• W1486908736 cites W1965734230 @default.
• W1486908736 cites W1966568422 @default.
• W1486908736 cites W1967029216 @default.
• W1486908736 cites W1967357725 @default.
• W1486908736 cites W1968788534 @default.
• W1486908736 cites W1969328947 @default.
• W1486908736 cites W1969807455 @default.
• W1486908736 cites W1972144299 @default.
• W1486908736 cites W1973690102 @default.
• W1486908736 cites W1974245070 @default.
• W1486908736 cites W1979349559 @default.
• W1486908736 cites W1980170092 @default.
• W1486908736 cites W1981570640 @default.
• W1486908736 cites W1982301997 @default.
• W1486908736 cites W1985804074 @default.
• W1486908736 cites W1986926802 @default.
• W1486908736 cites W1988515793 @default.
• W1486908736 cites W1990841196 @default.
• W1486908736 cites W1991354261 @default.
• W1486908736 cites W1991982116 @default.
• W1486908736 cites W1993342975 @default.
• W1486908736 cites W1993437185 @default.
• W1486908736 cites W1995336840 @default.
• W1486908736 cites W1996813579 @default.
• W1486908736 cites W1998258610 @default.
• W1486908736 cites W1998291423 @default.
• W1486908736 cites W2001282311 @default.
• W1486908736 cites W2003051577 @default.
• W1486908736 cites W2004877384 @default.
• W1486908736 cites W2004935367 @default.
• W1486908736 cites W2005482320 @default.
• W1486908736 cites W2006621710 @default.
• W1486908736 cites W2007257051 @default.
• W1486908736 cites W2009740718 @default.
• W1486908736 cites W2010397777 @default.
• W1486908736 cites W2012852444 @default.
• W1486908736 cites W2013801793 @default.
• W1486908736 cites W2013881657 @default.
• W1486908736 cites W2016326057 @default.
• W1486908736 cites W2016441400 @default.
• W1486908736 cites W2017695210 @default.
• W1486908736 cites W2017937144 @default.
• W1486908736 cites W201808626 @default.
• W1486908736 cites W2018836029 @default.
• W1486908736 cites W2019738273 @default.
• W1486908736 cites W2020344797 @default.
• W1486908736 cites W2022569128 @default.
• W1486908736 cites W2025370752 @default.
• W1486908736 cites W2027884969 @default.
• W1486908736 cites W2030080487 @default.
• W1486908736 cites W2030976397 @default.
• W1486908736 cites W2031469256 @default.
• W1486908736 cites W2032298890 @default.
• W1486908736 cites W2034642746 @default.
• W1486908736 cites W2034915619 @default.
• W1486908736 cites W2034994778 @default.
• W1486908736 cites W2035523654 @default.
• W1486908736 cites W2036367876 @default.
• W1486908736 cites W2036546668 @default.
• W1486908736 cites W2036729445 @default.
• W1486908736 cites W2040382500 @default.
• W1486908736 cites W2043141000 @default.
• W1486908736 cites W2044713924 @default.
• W1486908736 cites W2044973258 @default.
• W1486908736 cites W2045382498 @default.
• W1486908736 cites W2046848104 @default.
• W1486908736 cites W2048263097 @default.
• W1486908736 cites W2049598883 @default.
• W1486908736 cites W2049608177 @default.
• W1486908736 cites W2050140523 @default.
• W1486908736 cites W2052521108 @default.
• W1486908736 cites W2053857836 @default.

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