FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1487127761> ?p ?o ?g. }

• W1487127761 endingPage "1456" @default.
• W1487127761 startingPage "1444" @default.
• W1487127761 abstract "Current treatments for cancer pain are often inadequate, particularly when metastasis to bone is involved. The addition to the treatment regimen of another drug that has a complementary analgesic effect may increase the overall analgesia without the necessity to increase doses, thus avoiding dose-related side effects. This project investigated the synergistic effect of the addition of the potassium channel (KCNQ2-3) modulator flupirtine to morphine treatment in a rat model of prostate cancer-induced bone pain.Syngeneic prostate cancer cells were injected into the right tibia of male Wistar rats under anesthesia. This led to expanding tumor within the bone in 2 weeks, together with the concurrent development of hyperalgesia to noxious heat. Paw withdrawal thresholds from noxious heat were measured before and after the maximum non-sedating doses of morphine and flupirtine given alone and in combinations. Dose-response curves for morphine (0.13-5.0 mg/kg ip) and flupirtine (1.25-10.0 mg/kg ip) given alone and in fixed-dose combinations were plotted and subjected to an isobolographic analysis.Both morphine (ED₅₀ = 0.74 mg/kg) and flupirtine (ED₅₀ = 3.32 mg/kg) caused dose-related anti-hyperalgesia at doses that did not cause sedation. Isobolographic analysis revealed that there was a synergistic interaction between flupirtine and morphine. Addition of flupirtine to morphine treatment improved morphine anti-hyperalgesia, and resulted in the reversal of cancer-induced heat hyperalgesia.These results suggest that flupirtine in combination with morphine may be useful clinically to provide better analgesia at lower morphine doses in the management of pain caused by tumors growing in bone." @default.
• W1487127761 created "2016-06-24" @default.
• W1487127761 creator A5002078578 @default.
• W1487127761 creator A5024431392 @default.
• W1487127761 creator A5028353412 @default.
• W1487127761 creator A5052143564 @default.
• W1487127761 date "2012-11-01" @default.
• W1487127761 modified "2023-09-27" @default.
• W1487127761 title "Flupirtine Enhances the Anti-Hyperalgesic Effects of Morphine in a Rat Model of Prostate Bone Metastasis" @default.
• W1487127761 cites W1720952724 @default.
• W1487127761 cites W1896223819 @default.
• W1487127761 cites W1935006995 @default.
• W1487127761 cites W1967912161 @default.
• W1487127761 cites W1970892256 @default.
• W1487127761 cites W1978283158 @default.
• W1487127761 cites W1981211047 @default.
• W1487127761 cites W1983679136 @default.
• W1487127761 cites W1985689777 @default.
• W1487127761 cites W1999671651 @default.
• W1487127761 cites W2002508551 @default.
• W1487127761 cites W2003071360 @default.
• W1487127761 cites W2010347594 @default.
• W1487127761 cites W2012346691 @default.
• W1487127761 cites W2012553144 @default.
• W1487127761 cites W2013547432 @default.
• W1487127761 cites W2014007136 @default.
• W1487127761 cites W2014670473 @default.
• W1487127761 cites W2016107365 @default.
• W1487127761 cites W2017865504 @default.
• W1487127761 cites W2023338676 @default.
• W1487127761 cites W2038535670 @default.
• W1487127761 cites W2038821800 @default.
• W1487127761 cites W2039286479 @default.
• W1487127761 cites W2039982019 @default.
• W1487127761 cites W2051192926 @default.
• W1487127761 cites W2053916112 @default.
• W1487127761 cites W2076335691 @default.
• W1487127761 cites W2080684231 @default.
• W1487127761 cites W2087454739 @default.
• W1487127761 cites W2107448778 @default.
• W1487127761 cites W2113011586 @default.
• W1487127761 cites W2124339046 @default.
• W1487127761 cites W2127457810 @default.
• W1487127761 cites W2127461273 @default.
• W1487127761 cites W2132469876 @default.
• W1487127761 cites W2139861802 @default.
• W1487127761 cites W2158225751 @default.
• W1487127761 cites W2396939494 @default.
• W1487127761 cites W2398730908 @default.
• W1487127761 cites W2400057405 @default.
• W1487127761 cites W2568896786 @default.
• W1487127761 cites W2887714295 @default.
• W1487127761 doi "https://doi.org/10.1111/j.1526-4637.2012.01502.x" @default.
• W1487127761 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23078152" @default.
• W1487127761 hasPublicationYear "2012" @default.
• W1487127761 type Work @default.
• W1487127761 sameAs 1487127761 @default.
• W1487127761 citedByCount "19" @default.
• W1487127761 countsByYear W14871277612013 @default.
• W1487127761 countsByYear W14871277612014 @default.
• W1487127761 countsByYear W14871277612015 @default.
• W1487127761 countsByYear W14871277612016 @default.
• W1487127761 countsByYear W14871277612017 @default.
• W1487127761 countsByYear W14871277612019 @default.
• W1487127761 countsByYear W14871277612020 @default.
• W1487127761 countsByYear W14871277612021 @default.
• W1487127761 countsByYear W14871277612023 @default.
• W1487127761 crossrefType "journal-article" @default.
• W1487127761 hasAuthorship W1487127761A5002078578 @default.
• W1487127761 hasAuthorship W1487127761A5024431392 @default.
• W1487127761 hasAuthorship W1487127761A5028353412 @default.
• W1487127761 hasAuthorship W1487127761A5052143564 @default.
• W1487127761 hasBestOaLocation W14871277611 @default.
• W1487127761 hasConcept C121608353 @default.
• W1487127761 hasConcept C126322002 @default.
• W1487127761 hasConcept C15490471 @default.
• W1487127761 hasConcept C170493617 @default.
• W1487127761 hasConcept C2776035513 @default.
• W1487127761 hasConcept C2776814716 @default.
• W1487127761 hasConcept C2777389121 @default.
• W1487127761 hasConcept C2779245659 @default.
• W1487127761 hasConcept C2780192828 @default.
• W1487127761 hasConcept C2780820201 @default.
• W1487127761 hasConcept C42219234 @default.
• W1487127761 hasConcept C71924100 @default.
• W1487127761 hasConcept C98274493 @default.
• W1487127761 hasConceptScore W1487127761C121608353 @default.
• W1487127761 hasConceptScore W1487127761C126322002 @default.
• W1487127761 hasConceptScore W1487127761C15490471 @default.
• W1487127761 hasConceptScore W1487127761C170493617 @default.
• W1487127761 hasConceptScore W1487127761C2776035513 @default.
• W1487127761 hasConceptScore W1487127761C2776814716 @default.
• W1487127761 hasConceptScore W1487127761C2777389121 @default.
• W1487127761 hasConceptScore W1487127761C2779245659 @default.
• W1487127761 hasConceptScore W1487127761C2780192828 @default.
• W1487127761 hasConceptScore W1487127761C2780820201 @default.
• W1487127761 hasConceptScore W1487127761C42219234 @default.
• W1487127761 hasConceptScore W1487127761C71924100 @default.

• next