FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1487174505> ?p ?o ?g. }

• W1487174505 abstract "Brain morphometric abnormalities in schizophrenia have been extensively reported in the literature. Whole-brain volumetric reductions are almost universally reported by most studies irrespective of the characteristics of the samples studied (e.g., chronic/recent-onset; medicated/neuroleptic-naïve etc.). However, the same cannot be said of the reported regional morphometric abnormalities in schizophrenia. While certain regional morphometric abnormalities are more frequently reported than others, there are no such abnormalities that are universally reported across studies. Variability of socio-demographic and clinical characteristics across study samples as well as technical and methodological issues related to acquisition and analyses of brain structural images may contribute to inconsistency of brain morphometric findings in schizophrenia. The objective of the present study therefore was to systematically examine brain morphometry in patients with recent-onset schizophrenia to find out if there are significant whole-brain or regional volumetric differences detectable at the appropriate significance threshold, after attempting to control for various confounding factors that could impact brain volumes.Structural magnetic resonance images of 90 subjects (schizophrenia = 45; healthy subjects = 45) were acquired using a 3 Tesla magnet. Morphometric analyses were carried out following standard analyses pipelines of three most commonly used strategies, viz., whole-brain voxel-based morphometry, whole-brain surface-based morphometry, and between-group comparisons of regional volumes generated by automated segmentation and parcellation.In our sample of patients having recent-onset schizophrenia with limited neuroleptic exposure, there were no significant whole brain or regional brain morphometric abnormalities noted at the appropriate statistical significance thresholds with or without including age, gender and intracranial volume or total brain volume in the statistical analyses.In the background of the conflicting findings in the literature, our findings indicate that brain morphometric abnormalities may not be directly related to the schizophrenia phenotype. Analysis of the reasons for the inconsistent results across studies as well as consideration of alternate sources of variability of brain morphology in schizophrenia such as epistatic and epigenetic mechanisms could perhaps advance our understanding of structural brain alterations in schizophrenia." @default.
• W1487174505 created "2016-06-24" @default.
• W1487174505 creator A5024796422 @default.
• W1487174505 creator A5026751784 @default.
• W1487174505 creator A5029109839 @default.
• W1487174505 creator A5054241852 @default.
• W1487174505 creator A5056326301 @default.
• W1487174505 creator A5065718043 @default.
• W1487174505 creator A5086645149 @default.
• W1487174505 date "2015-06-12" @default.
• W1487174505 modified "2023-09-27" @default.
• W1487174505 title "A systematic examination of brain volumetric abnormalities in recent-onset schizophrenia using voxel-based, surface-based and region-of-interest-based morphometric analyses" @default.
• W1487174505 cites W177664770 @default.
• W1487174505 cites W1847168837 @default.
• W1487174505 cites W1967197357 @default.
• W1487174505 cites W1967979754 @default.
• W1487174505 cites W197326298 @default.
• W1487174505 cites W1979416282 @default.
• W1487174505 cites W1982059964 @default.
• W1487174505 cites W1985994929 @default.
• W1487174505 cites W2004559917 @default.
• W1487174505 cites W2006096283 @default.
• W1487174505 cites W2008854521 @default.
• W1487174505 cites W2010569051 @default.
• W1487174505 cites W2011228295 @default.
• W1487174505 cites W2012410605 @default.
• W1487174505 cites W2015779008 @default.
• W1487174505 cites W2022320465 @default.
• W1487174505 cites W2035734158 @default.
• W1487174505 cites W2041689182 @default.
• W1487174505 cites W2043564452 @default.
• W1487174505 cites W2049776382 @default.
• W1487174505 cites W2050536595 @default.
• W1487174505 cites W2050769504 @default.
• W1487174505 cites W2058161128 @default.
• W1487174505 cites W2071980369 @default.
• W1487174505 cites W2073966674 @default.
• W1487174505 cites W2074067530 @default.
• W1487174505 cites W2083645773 @default.
• W1487174505 cites W2090969707 @default.
• W1487174505 cites W2097745749 @default.
• W1487174505 cites W2098924721 @default.
• W1487174505 cites W2101135654 @default.
• W1487174505 cites W2102076075 @default.
• W1487174505 cites W2102122784 @default.
• W1487174505 cites W2102254199 @default.
• W1487174505 cites W2103691876 @default.
• W1487174505 cites W2104384019 @default.
• W1487174505 cites W2108053280 @default.
• W1487174505 cites W2112057496 @default.
• W1487174505 cites W2117038895 @default.
• W1487174505 cites W2117220391 @default.
• W1487174505 cites W2117987967 @default.
• W1487174505 cites W2124588234 @default.
• W1487174505 cites W2131287696 @default.
• W1487174505 cites W2131564374 @default.
• W1487174505 cites W2140606211 @default.
• W1487174505 cites W2141265734 @default.
• W1487174505 cites W2144981148 @default.
• W1487174505 cites W2145240519 @default.
• W1487174505 cites W2147655416 @default.
• W1487174505 cites W2148080316 @default.
• W1487174505 cites W2151130155 @default.
• W1487174505 cites W2156123885 @default.
• W1487174505 cites W2157885417 @default.
• W1487174505 cites W2158308713 @default.
• W1487174505 cites W2162950935 @default.
• W1487174505 cites W2166793287 @default.
• W1487174505 cites W2167311298 @default.
• W1487174505 cites W2168362300 @default.
• W1487174505 cites W2169662981 @default.
• W1487174505 cites W2170644672 @default.
• W1487174505 cites W2206955164 @default.
• W1487174505 cites W2259591919 @default.
• W1487174505 cites W4297872986 @default.
• W1487174505 cites W74146668 @default.
• W1487174505 cites W2245231029 @default.
• W1487174505 doi "https://doi.org/10.1186/s12952-015-0030-z" @default.
• W1487174505 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4464994" @default.
• W1487174505 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26065881" @default.
• W1487174505 hasPublicationYear "2015" @default.
• W1487174505 type Work @default.
• W1487174505 sameAs 1487174505 @default.
• W1487174505 citedByCount "8" @default.
• W1487174505 countsByYear W14871745052016 @default.
• W1487174505 countsByYear W14871745052019 @default.
• W1487174505 countsByYear W14871745052020 @default.
• W1487174505 countsByYear W14871745052021 @default.
• W1487174505 countsByYear W14871745052022 @default.
• W1487174505 countsByYear W14871745052023 @default.
• W1487174505 crossrefType "journal-article" @default.
• W1487174505 hasAuthorship W1487174505A5024796422 @default.
• W1487174505 hasAuthorship W1487174505A5026751784 @default.
• W1487174505 hasAuthorship W1487174505A5029109839 @default.
• W1487174505 hasAuthorship W1487174505A5054241852 @default.
• W1487174505 hasAuthorship W1487174505A5056326301 @default.
• W1487174505 hasAuthorship W1487174505A5065718043 @default.
• W1487174505 hasAuthorship W1487174505A5086645149 @default.
• W1487174505 hasBestOaLocation W14871745051 @default.
• W1487174505 hasConcept C118552586 @default.

• next