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- W1487177791 abstract "The conversion of local anesthetics in human cerebro-spinal fluid was investigated in vitro and an improved method for analysis of the local anesthetics in cerebro-spinal fluid was proposed. When hexylcaine, procaine and tetracaine were incubated with cerebro-spinal fluid, ester bonds of the compounds were hydrolysed mainly due to the increase of pH of cerebro-spinal fluid on standing, while amide bonds of dibucaine, lidocaine and carbocaine were unchanged. In the analysis of local anesthetics in cerebro-spinal fluid, it is desirable to estimate the ultra-violet spectrum of the sample and to determine the aromatic carboxylic acid liberated, as well as the determination of the unchanged anesthetics." @default.
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- W1487177791 date "1966-01-01" @default.
- W1487177791 modified "2023-10-17" @default.
- W1487177791 title "Microanalysis of Local Anesthetics (III) : On the Analysis of Local Anesthetics in Cerebro-spinal Fluid" @default.
- W1487177791 doi "https://doi.org/10.1248/jhs1956.12.138" @default.
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