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• W1487203486 abstract "Introduction: Incidence of non-Hodgkin lymphoma (NHL) has increased greatly over time, especially in children. Improved diagnostic methods alone cannot explain this increase, especially the increase observed in sub-Saharan Africa, where diagnostic capabilities are low. Objectives and aims: The objectives of this study were to better understand known risk factors for NHL, such as Epstein-Barr virus (EBV), and their impact on disease characteristics. The specific aims were: I. to understand the background role of EBV, II. to elucidate the basis for and strength of the diagnosis of childhood NHL in Uganda, III. to highlight trends in characteristics of childhood NHL, and IV. to examine the impact of human immunodeficiency virus (HIV) infection.Subject and Method: Aims I and II were studied in Papers I and II using samples and data from a case-control study carried out at the Mulago National Referral Hospital between 2004 and 2008. This study enrolled children with suspected tumours or masses referred to the Departments of Paediatrics, Paediatric surgery, Orthopaedics and to the Uganda Cancer Institute. In Paper I, EBV viral load was measured in saliva, whole blood, and white blood cells by real-time PCR, serological values for IgG-VCA, EBNA1, and EAd-IgG were measured and compared in NHL and chronic inflammatory conditions (CIC). Comparisons were also done by NHL subtypes (Burkitt lymphoma, BL and other NHL). Odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were calculated. In Paper II children were diagnosed with suspected NHL based on initial clinical examination; tissue samples were then taken and examined in Uganda and sent thereafter to a pathology laboratory in The Netherlands for re-examination and additional tests. Agreement between diagnoses assigned in Uganda and The Netherlands were compared using kappa statistics.For aims III and IV a review of routine clinical records of paediatric BL patients seen at the Uganda Cancer Institute was done and reported in Papers III and IV. Information on demographic characteristics (age and sex), clinical features (symptoms, signs, disease site, and stage), treatment response and vital status information were obtained. In Paper III the frequency distribution of the clinical characteristics, treatment, and outcome of childhood BL over 20 years were summarised by means and standard deviations (SD), or proportions; differences were tested by the 2 test, t-test, z-test or analysis of variance (ANOVA) procedures. In Paper IV descriptive statistics of frequencies, means and SD were done using Student’s t-test and Chi-square test statistic and ORs, CIs and P-values were obtained. Survival analysis was performed using the Kaplan-Meier method.Results: In Paper I the most common clinical presentations were fever, night sweats and weight loss. EBV viral load in blood was elevated in BL vs other NHL (OR 6.67, 95% CI 1.32-33.69; P-value=0.04) and a significant difference in EAd-IgG was observed in NHL vs CIC (OR 0.19, 95% CI 0.07-0.51; P-value=0.001). In Paper II, the agreement between clinical and pathological diagnoses of NHL in Uganda was 91% (95% CI 84-95; kappa 0.84; P-value=0.001). The agreement between clinical diagnoses in Uganda and pathological diagnoses in The Netherlands was 49% (95% CI 40-59; kappa 0.04; P-value=0.612). The agreement between all pathological diagnoses assigned in Uganda and The Netherlands was36% (95% CI 28-46; kappa 0.11; P-value=0.046). In Paper III, facial tumour (n=945, 77.65%) and abdominal disease (n=842, 69.19%) were the most common presentations. Significant presentation with advanced-stage disease (hepatic mass, malignant pleocytosis) was noted (P-value <0.01). Mortality was higher in older children, children with advanced- stage BL, and HIV-positive children. In Paper IV HIV-positive children presented significantly more often with disease in the lymph nodes (67%), liver (51%), and chest (10%). Response to chemotherapy was similar in HIV-positive and HIV-negative children although survival was poorer in HIV-positive children (median survival of 11.79 months, 95% CI 8.65-14.92; P-value<0.000).Conclusion: This study provides additional understanding of the role of EBV in childhood NHL, shown by the significant association between virological and serological markers and common general features, suggesting a common factor. We noted a weak basis for diagnosis of childhood NHL in Uganda with a high probability of error. The presenting features of childhood NHL have not changed with time, although more children present late, especially those with HIV. Improvements in the cancer care system in Uganda should include better diagnostic and treatment services for children as a basis for better understanding of disease and high-quality research." @default.
• W1487203486 created "2016-06-24" @default.
• W1487203486 creator A5035455400 @default.
• W1487203486 date "2014-08-14" @default.
• W1487203486 modified "2023-09-27" @default.
• W1487203486 title "Etiological risk factors and clinical characteristics of childhood non-Hodgkin lymphoma in Uganda" @default.
• W1487203486 cites W11174045 @default.
• W1487203486 cites W135964243 @default.
• W1487203486 cites W1488068570 @default.
• W1487203486 cites W1531385547 @default.
• W1487203486 cites W155781577 @default.
• W1487203486 cites W1558727349 @default.
• W1487203486 cites W1578954095 @default.
• W1487203486 cites W1591921354 @default.
• W1487203486 cites W16678061 @default.
• W1487203486 cites W1735455912 @default.
• W1487203486 cites W178345718 @default.
• W1487203486 cites W1792808628 @default.
• W1487203486 cites W1867200418 @default.
• W1487203486 cites W1908138796 @default.
• W1487203486 cites W1941328144 @default.
• W1487203486 cites W1964088794 @default.
• W1487203486 cites W1965014372 @default.
• W1487203486 cites W1966926581 @default.
• W1487203486 cites W1968116853 @default.
• W1487203486 cites W1968989618 @default.
• W1487203486 cites W1971628209 @default.
• W1487203486 cites W1974994233 @default.
• W1487203486 cites W1976859150 @default.
• W1487203486 cites W1977891415 @default.
• W1487203486 cites W1978134605 @default.
• W1487203486 cites W1979625601 @default.
• W1487203486 cites W1981933607 @default.
• W1487203486 cites W1983356182 @default.
• W1487203486 cites W1984001033 @default.
• W1487203486 cites W1988055831 @default.
• W1487203486 cites W1989435822 @default.
• W1487203486 cites W1989469346 @default.
• W1487203486 cites W1993049441 @default.
• W1487203486 cites W1994124254 @default.
• W1487203486 cites W1997908398 @default.
• W1487203486 cites W1997975814 @default.
• W1487203486 cites W2003922875 @default.
• W1487203486 cites W2006200510 @default.
• W1487203486 cites W2007397303 @default.
• W1487203486 cites W2008719487 @default.
• W1487203486 cites W2013886789 @default.
• W1487203486 cites W2013956239 @default.
• W1487203486 cites W2014462867 @default.
• W1487203486 cites W2015098191 @default.
• W1487203486 cites W2018528339 @default.
• W1487203486 cites W2019490105 @default.
• W1487203486 cites W2021418079 @default.
• W1487203486 cites W2022453861 @default.
• W1487203486 cites W2024095683 @default.
• W1487203486 cites W2024667058 @default.
• W1487203486 cites W2024911212 @default.
• W1487203486 cites W2027585649 @default.
• W1487203486 cites W2028937767 @default.
• W1487203486 cites W2030351573 @default.
• W1487203486 cites W2031180703 @default.
• W1487203486 cites W2031435888 @default.
• W1487203486 cites W2033791981 @default.
• W1487203486 cites W2034459005 @default.
• W1487203486 cites W2036320218 @default.
• W1487203486 cites W2040742962 @default.
• W1487203486 cites W2041304996 @default.
• W1487203486 cites W2043358123 @default.
• W1487203486 cites W2044161165 @default.
• W1487203486 cites W2047505785 @default.
• W1487203486 cites W2050063671 @default.
• W1487203486 cites W2050355959 @default.
• W1487203486 cites W2052904414 @default.
• W1487203486 cites W2056659962 @default.
• W1487203486 cites W2061621929 @default.
• W1487203486 cites W2065949429 @default.
• W1487203486 cites W2068800394 @default.
• W1487203486 cites W2070106785 @default.
• W1487203486 cites W2072365996 @default.
• W1487203486 cites W2072708324 @default.
• W1487203486 cites W2074767700 @default.
• W1487203486 cites W2074941867 @default.
• W1487203486 cites W2075001839 @default.
• W1487203486 cites W2075469860 @default.
• W1487203486 cites W2075959359 @default.
• W1487203486 cites W2076936182 @default.
• W1487203486 cites W2077039285 @default.
• W1487203486 cites W2080157106 @default.
• W1487203486 cites W2081878197 @default.
• W1487203486 cites W2082162213 @default.
• W1487203486 cites W2083210511 @default.
• W1487203486 cites W2083278363 @default.
• W1487203486 cites W2087222465 @default.
• W1487203486 cites W2094003334 @default.
• W1487203486 cites W2097254316 @default.
• W1487203486 cites W2098560717 @default.
• W1487203486 cites W2100097418 @default.
• W1487203486 cites W2100376205 @default.
• W1487203486 cites W2100541738 @default.
• W1487203486 cites W2100649361 @default.

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