Matches in SemOpenAlex for { <https://semopenalex.org/work/W1487345446> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W1487345446 endingPage "60" @default.
- W1487345446 startingPage "39" @default.
- W1487345446 abstract "Proteasome is an exceptional enzyme because of its essential physiological role, multiple activities, and structural complexity. It is, in fact, a family of enzymes sharing a common catalytic core and equipped with distinct protein attachments regulating the core and adding to its new functional capabilities. As a drug target and a major regulator of cellular processes, proteasome is extensively studied with tools of structural, biochemical, and molecular biology. Atomic force microscopy (AFM) besides X‐ray crystallography and electron microscopy is one of the most attractive methods to study proteasome. The noninvasive nature of this method is particularly well suited for investigating the structure–function relationship within the core particle (CP) as well as in higher‐order assemblies. Here we review, from the methodological point of view, AFM‐based studies on the proteasome. First, we will present the application of height distribution analysis of proteasome complexes to dissect the subunit organization in the base of the regulatory particle (RP). The RP is considered the most physiologically important among all the attachments of the CP; however, its structure remains enigmatic. Then, we will outline the use of AFM imaging to research on structural dynamics of the proteasome, a phenomenon which is starting to gain a broad interest. We will finish with a brief presentation of nanotechnological studies performed using ordered proteasomes and nanolithography carried out with the particles. The presented AFM research offers a unique and often unexpected insight into the structure and function of the proteasome." @default.
- W1487345446 created "2016-06-24" @default.
- W1487345446 creator A5042702595 @default.
- W1487345446 creator A5052675055 @default.
- W1487345446 date "2008-01-01" @default.
- W1487345446 modified "2023-09-23" @default.
- W1487345446 title "Chapter 3 Atomic Force Microscopy as a Tool to Study the Proteasome Assemblies" @default.
- W1487345446 cites W1963906290 @default.
- W1487345446 cites W1964602059 @default.
- W1487345446 cites W1972120339 @default.
- W1487345446 cites W1972432934 @default.
- W1487345446 cites W1975460230 @default.
- W1487345446 cites W1991764480 @default.
- W1487345446 cites W1999119754 @default.
- W1487345446 cites W2000596494 @default.
- W1487345446 cites W2001966304 @default.
- W1487345446 cites W2004557152 @default.
- W1487345446 cites W2006819428 @default.
- W1487345446 cites W2008609697 @default.
- W1487345446 cites W2012462500 @default.
- W1487345446 cites W2014349449 @default.
- W1487345446 cites W2068454239 @default.
- W1487345446 cites W2076369656 @default.
- W1487345446 cites W2079052273 @default.
- W1487345446 cites W2083133408 @default.
- W1487345446 cites W2084706485 @default.
- W1487345446 cites W2086301454 @default.
- W1487345446 cites W2090381083 @default.
- W1487345446 cites W2118397817 @default.
- W1487345446 cites W2119883540 @default.
- W1487345446 cites W2142316927 @default.
- W1487345446 cites W2149681209 @default.
- W1487345446 cites W2153890737 @default.
- W1487345446 cites W2154539002 @default.
- W1487345446 cites W2163495162 @default.
- W1487345446 doi "https://doi.org/10.1016/s0091-679x(08)00803-0" @default.
- W1487345446 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19195545" @default.
- W1487345446 hasPublicationYear "2008" @default.
- W1487345446 type Work @default.
- W1487345446 sameAs 1487345446 @default.
- W1487345446 citedByCount "0" @default.
- W1487345446 crossrefType "book-chapter" @default.
- W1487345446 hasAuthorship W1487345446A5042702595 @default.
- W1487345446 hasAuthorship W1487345446A5052675055 @default.
- W1487345446 hasConcept C102951782 @default.
- W1487345446 hasConcept C104292427 @default.
- W1487345446 hasConcept C104317684 @default.
- W1487345446 hasConcept C12554922 @default.
- W1487345446 hasConcept C14036430 @default.
- W1487345446 hasConcept C171250308 @default.
- W1487345446 hasConcept C185592680 @default.
- W1487345446 hasConcept C192562407 @default.
- W1487345446 hasConcept C27740335 @default.
- W1487345446 hasConcept C55493867 @default.
- W1487345446 hasConcept C6929976 @default.
- W1487345446 hasConcept C70721500 @default.
- W1487345446 hasConcept C86803240 @default.
- W1487345446 hasConcept C95444343 @default.
- W1487345446 hasConceptScore W1487345446C102951782 @default.
- W1487345446 hasConceptScore W1487345446C104292427 @default.
- W1487345446 hasConceptScore W1487345446C104317684 @default.
- W1487345446 hasConceptScore W1487345446C12554922 @default.
- W1487345446 hasConceptScore W1487345446C14036430 @default.
- W1487345446 hasConceptScore W1487345446C171250308 @default.
- W1487345446 hasConceptScore W1487345446C185592680 @default.
- W1487345446 hasConceptScore W1487345446C192562407 @default.
- W1487345446 hasConceptScore W1487345446C27740335 @default.
- W1487345446 hasConceptScore W1487345446C55493867 @default.
- W1487345446 hasConceptScore W1487345446C6929976 @default.
- W1487345446 hasConceptScore W1487345446C70721500 @default.
- W1487345446 hasConceptScore W1487345446C86803240 @default.
- W1487345446 hasConceptScore W1487345446C95444343 @default.
- W1487345446 hasLocation W14873454461 @default.
- W1487345446 hasLocation W14873454462 @default.
- W1487345446 hasOpenAccess W1487345446 @default.
- W1487345446 hasPrimaryLocation W14873454461 @default.
- W1487345446 hasRelatedWork W1999823311 @default.
- W1487345446 hasRelatedWork W2002020533 @default.
- W1487345446 hasRelatedWork W2004316415 @default.
- W1487345446 hasRelatedWork W2014146865 @default.
- W1487345446 hasRelatedWork W2041335388 @default.
- W1487345446 hasRelatedWork W2067788866 @default.
- W1487345446 hasRelatedWork W2233765393 @default.
- W1487345446 hasRelatedWork W2767930562 @default.
- W1487345446 hasRelatedWork W2899084033 @default.
- W1487345446 hasRelatedWork W4298175596 @default.
- W1487345446 isParatext "false" @default.
- W1487345446 isRetracted "false" @default.
- W1487345446 magId "1487345446" @default.
- W1487345446 workType "book-chapter" @default.