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• W1487347788 abstract "Adhesion molecule upregulation occurs in inflammatory myopathies, and is one of the myriad functions of tumor necrosis factor-α (TNF-α). TNF-α acts via two different receptors of 55 (TNF-R55) and 75 kD (TNF-R75). We immunolocalized TNF-α and its receptors in polymyositis, inclusion body myositis and dermatomyositis. In each myopathy, TNF-α was detected in macrophages, in myonuclei in regenerating muscle fibers, and freely dispersed in endomysial or perimysial connective tissue. Many endothelial cells in dermatomyositis expressed TNF-α. TNF-R55 was strongly expressed on myonuclei of regenerating muscle fibers. TNF-R75 was increased on endothelial cells in the midst of inflammatory infiltrates in each myopathy, and on perifascicular and perimysial endothelia, remote from inflammatory foci in dermatomyositis. Possible TNF-α-mediated effects include: increased transendothelial cell trafficking, activation of T/B cells and macrophages, induction of MHC-I gene products, and focal muscle fiber atrophy. In dermatomyositis, the upregulated TNF-R75, via its consensus elements for transcription factors, may be involved in endothelial cell degeneration. Strong TNF-R55 expression on regenerating myonuclei is consistent with a role of TNF-α and TNF-R55 in muscle regeneration." @default.
• W1487347788 created "2016-06-24" @default.
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• W1487347788 date "1999-06-01" @default.
• W1487347788 modified "2023-10-14" @default.
• W1487347788 title "Immunolocalization of tumor necrosis factor-alpha and its receptors in inflammatory myopathies1This paper was presented at the 50th Annual Meeting of the American Academy of Neurology, Minneapolis, MN, USA, April 1998.1" @default.
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• W1487347788 doi "https://doi.org/10.1016/s0960-8966(98)00126-6" @default.
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