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• W1487355304 endingPage "843" @default.
• W1487355304 startingPage "838" @default.
• W1487355304 abstract "The simultaneous use of several drugs (polypharmacy) for the treatment of cancer, HIV, and other diseases and for multiple ailments of the elderly is a common practice in modern medicine. Co-administration of drugs may result in unwanted side effects. One reason for these side effects can be the altered function of transport proteins, especially of P-glycoprotein (Pgp), due to its simultaneous interaction with several drugs. We describe here some of the observed, unexpected side effects of polypharmacy in the clinic. We also describe intentional modulation of the function of Pgp that is introduced when facilitation of absorption of a drug through the intestines is needed and in cancer chemotherapy. In addition, we mention some methods of testing and ways by which doctors and patients can be alerted to potential side effects." @default.
• W1487355304 created "2016-06-24" @default.
• W1487355304 creator A5089312314 @default.
• W1487355304 date "2007-10-01" @default.
• W1487355304 modified "2023-10-12" @default.
• W1487355304 title "Drug–drug interactions affected by the transporter protein, P-glycoprotein (ABCB1, MDR1)" @default.
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• W1487355304 doi "https://doi.org/10.1016/j.drudis.2007.07.021" @default.
• W1487355304 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17933685" @default.
• W1487355304 hasPublicationYear "2007" @default.
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