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- W14874507 abstract "We have examined the role and recognition patterns of influenza-specific cytotoxic T cells (Tc) in a mouse model of influenza infection. Recent work has shown that influenza nucleoprotein (NP) is an important target antigen for the type A virus cross-reactive and class I MHC-restricted Tc cells, although by no means the only one. There are striking genetic differences in Tc recognition of NP and we find three nonresponder class I MHC alleles in three mouse haplotypes (Kb, DdLd, Dk), while only Kb is a low-responder allele for infective virus. With regard to NP peptide recognition by Tc, the genetic differences are even greater. NP-specific Tc clones can protect mice against a lethal PR8 infection and limit virus replication in vivo and this can be achieved by priming hosts with a purified NP preparation. Cloned T-helper (TH) cells are less effective in protection, and those with hemagglutinin (HA) specificity can exacerbate virus replication. Although TH or Tc clones release similar amounts of immune IFN, TH induce stronger delayed-type hypersensitivity (DTH) reactions that may interfere in their protective ability." @default.
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- W14874507 date "1986-01-01" @default.
- W14874507 modified "2023-10-18" @default.
- W14874507 title "Cytotoxic T Cells in Influenza: Their Role and Viral Specificities" @default.
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- W14874507 doi "https://doi.org/10.1016/b978-0-12-174685-8.50077-9" @default.
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