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• W1487496851 abstract "1.The development profiles of the phosphatidic acid phosphohydrolase activities in developing rat lung were determined using aqueously dispersed phosphatidic acid (PAaq), membrane-bound phosphatidic acid (PAmb) and lipid vesicles (PA1v) prepared from extracts of PAm as the substrates. 2. The specific activities of the PAaq-dependent phosphohydrolase activities in the homogenates, microsomes or cytosol did not change appreciably prior to birth but the microsomal and to a lesser extent the homogenate activities increased after birth. The PAmb-and PA1v-dependent activities increased between 18–21 days gestation (term 22) and thereafter declined. 3. When the phosphatidic acid phosphohydrolase activities were expressed as total activity per g lung, a contrasting picture emerged. The increase in the PAaq-dependent activities in the microsomes and cytosol was also noted prior to birth. Although the increases in the PAmb- and PA1v-dependent activities were still apparent between 18–20 days gestation, the following decline noted with specific activities was less evident. These differences beween the developmental profiles with specific activities and total activities per g lung reflected changes in the protein contents. 4. Fractionation of adult rat lung cytosol on Bio-Gel A5m columns produced PAaq-dependent phosphohydrolase activities in the void volume and a major PAaq-dependent activity with an apparent molecular mass (Mr) of 130 kdaltons which was followed by a broad shoulder. The 130 kdalton activity peak was not present in fetal and +1 day neonatal cytosols but the shoulder was still present. 5. The PAmb-dependent phosphohydrolase activities eluted from the Bio-Gel A5m in the void volume, as a major activity with an apparent Mr = 390 kdaltons and a minor activity peak with an apparent Mr = 110 kdaltons. Except for an increase in the PAmb dependent activity eluting in the void volume, there was little change in the profile. 6. Thermal denaturation curves for the phosphatidic acid-dependent activities in fetal, neonatal and adult cytosols were biphasic with a rapidly inactivated component and a more slowly inactivated component. Little developmental change was noted in the thermal denaturation patterns of the PAmb-dependent activities. However, the thermal denaturation patterns of the PAaq-dependent activities revealed an increase in the heat stability of the more rapidly inactivated coponent with the +3 day neonatal and the adult cytosols." @default.
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• W1487496851 date "1981-08-01" @default.
• W1487496851 modified "2023-09-23" @default.
• W1487496851 title "Pulmonary phosphatidic acid phosphohydrolase" @default.
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• W1487496851 doi "https://doi.org/10.1016/0005-2760(81)90001-1" @default.
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