FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1487661421> ?p ?o ?g. }

• W1487661421 endingPage "58" @default.
• W1487661421 startingPage "51" @default.
• W1487661421 abstract "Introduction Although the pharmaceutical industry has well-developed project management methodologies for research, it is unusual for academic researchers working in the education and public sectors to do so. The discipline that these tools impose can appear alien initially and often require cultural change for the potential value they can bring to be recognised. This paper examines the experience of introducing a standard project management tool, PRINCE2, to the management of a large Phase III clinical trial, the Microbicides Development Programme (MDP). Phase III clinical trials are usually undertaken by the pharmaceutical industry. Somewhat unusually, the MDP is publicly funded and managed by a partnership of academic bodies. Funding is provided by the UK Department for International Development (DFID) and the programme is coordinated by the Medical Research Council Clinical Trials Unit, UK and Imperial College London, UK. The trial sites themselves are in Africa. The complexity of this particular trial, and the need to communicate and monitor progress against budget in a standard format to the funder, DFID, prompted senior academic staff to modify their approach to management and reporting through adopting elements of PRINCE2. This has proved beneficial for both the trial team and DFID. The paper describes what was done in the MDP case and discusses the costs and benefits of adopting a similar approach more widely in conducting academic-led clinical trials. The Microbicides Development Programme The Microbicides Development Programme (MDP) is a partnership to develop vaginal microbicides for the prevention of HIV transmission, funded by the UK Department for International Development (DFID) and the UK Medical Research Council, and coordinated by the Medical Research Council Clinical Trials Unit, UK and Imperial College London, UK. The central goal of the Partnership is to complete a Phase III trial of candidate microbicides in Africa. Phase III trials are randomised controlled trials on large patient/healthy volunteer groups (often enrolling several thousand individuals), and are aimed at definitively assessing the efficacy of a new therapy or prevention. Phase III trials are invariably expensive, time-consuming and complex to design and run. These trials look at whether the new treatment works and at any side effects it may cause. The MDP budget is GBP 42M (USD 75M) and involves thirteen principal scientific partner institutions, six of which are African. A large number of scientists and clinicians are involved in programme management functions in addition to their own areas of particular expertise. There are also a number of people focusing on specific areas, such as trial management and communication. Given the size of the management burden of a Phase III clinical trial and the need to communicate progress in a standard format to the funder, DFID, in a way that would reflect both the customary approaches to trial management and DFID's usual approach to reporting on projects (not designed specifically for clinical trials), senior academic staff opted to adopt an approach to project management based on PRINCE2 methodology. Features of PRINCE2 PRINCE is a structured method for achieving effective project management that has evolved in the UK. It was first established in 1989 by the UK Central Computer and Telecommunications Agency as a standard to be used for all government IT projects, and was subsequently developed as an approach to project management for all projects. Since 1996 it has been a standard requirement that UK public sector projects are run using this version of the approach, PRINCE2. Key features of the PRINCE2 approach include: 1) a clear business case, which sets out the aims of the project; 2) a defined and measurable set of products or results, together with the activities to achieve them; 3) defined resources linked to activities; and 4) an organisational structure, with defined responsibilities to manage the project (UK Office of Government Commerce) (Figure 1). …" @default.
• W1487661421 created "2016-06-24" @default.
• W1487661421 creator A5061406662 @default.
• W1487661421 creator A5071705704 @default.
• W1487661421 date "2007-09-22" @default.
• W1487661421 modified "2023-09-27" @default.
• W1487661421 title "Application of Standard Project Management Tools to Research--A Case Study from a Multi-National Clinical Trial." @default.
• W1487661421 hasPublicationYear "2007" @default.
• W1487661421 type Work @default.
• W1487661421 sameAs 1487661421 @default.
• W1487661421 citedByCount "8" @default.
• W1487661421 countsByYear W14876614212012 @default.
• W1487661421 countsByYear W14876614212017 @default.
• W1487661421 countsByYear W14876614212020 @default.
• W1487661421 crossrefType "journal-article" @default.
• W1487661421 hasAuthorship W1487661421A5061406662 @default.
• W1487661421 hasAuthorship W1487661421A5071705704 @default.
• W1487661421 hasConcept C10138342 @default.
• W1487661421 hasConcept C117214928 @default.
• W1487661421 hasConcept C142724271 @default.
• W1487661421 hasConcept C144133560 @default.
• W1487661421 hasConcept C17744445 @default.
• W1487661421 hasConcept C2908647359 @default.
• W1487661421 hasConcept C2986740045 @default.
• W1487661421 hasConcept C39549134 @default.
• W1487661421 hasConcept C535046627 @default.
• W1487661421 hasConcept C71750763 @default.
• W1487661421 hasConcept C71924100 @default.
• W1487661421 hasConcept C99454951 @default.
• W1487661421 hasConceptScore W1487661421C10138342 @default.
• W1487661421 hasConceptScore W1487661421C117214928 @default.
• W1487661421 hasConceptScore W1487661421C142724271 @default.
• W1487661421 hasConceptScore W1487661421C144133560 @default.
• W1487661421 hasConceptScore W1487661421C17744445 @default.
• W1487661421 hasConceptScore W1487661421C2908647359 @default.
• W1487661421 hasConceptScore W1487661421C2986740045 @default.
• W1487661421 hasConceptScore W1487661421C39549134 @default.
• W1487661421 hasConceptScore W1487661421C535046627 @default.
• W1487661421 hasConceptScore W1487661421C71750763 @default.
• W1487661421 hasConceptScore W1487661421C71924100 @default.
• W1487661421 hasConceptScore W1487661421C99454951 @default.
• W1487661421 hasIssue "2" @default.
• W1487661421 hasLocation W14876614211 @default.
• W1487661421 hasOpenAccess W1487661421 @default.
• W1487661421 hasPrimaryLocation W14876614211 @default.
• W1487661421 hasRelatedWork W1980900838 @default.
• W1487661421 hasRelatedWork W2003437151 @default.
• W1487661421 hasRelatedWork W2007167819 @default.
• W1487661421 hasRelatedWork W2026804070 @default.
• W1487661421 hasRelatedWork W2052137692 @default.
• W1487661421 hasRelatedWork W2059731004 @default.
• W1487661421 hasRelatedWork W2101454487 @default.
• W1487661421 hasRelatedWork W2117325009 @default.
• W1487661421 hasRelatedWork W2169936572 @default.
• W1487661421 hasRelatedWork W2210986457 @default.
• W1487661421 hasRelatedWork W2252448148 @default.
• W1487661421 hasRelatedWork W2396815578 @default.
• W1487661421 hasRelatedWork W2410757192 @default.
• W1487661421 hasRelatedWork W2442893961 @default.
• W1487661421 hasRelatedWork W2466969866 @default.
• W1487661421 hasRelatedWork W2516473520 @default.
• W1487661421 hasRelatedWork W2588040520 @default.
• W1487661421 hasRelatedWork W2606395300 @default.
• W1487661421 hasRelatedWork W2901863337 @default.
• W1487661421 hasRelatedWork W2906173346 @default.
• W1487661421 hasVolume "38" @default.
• W1487661421 isParatext "false" @default.
• W1487661421 isRetracted "false" @default.
• W1487661421 magId "1487661421" @default.
• W1487661421 workType "article" @default.