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• W1487669901 abstract "Research Article2 December 1996free access A possible involvement of TIF1 alpha and TIF1 beta in the epigenetic control of transcription by nuclear receptors. B. Le Douarin B. Le Douarin Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, Collège de France, Illkirch, France. Search for more papers by this author A. L. Nielsen A. L. Nielsen Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, Collège de France, Illkirch, France. Search for more papers by this author J. M. Garnier J. M. Garnier Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, Collège de France, Illkirch, France. Search for more papers by this author H. Ichinose H. Ichinose Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, Collège de France, Illkirch, France. Search for more papers by this author F. Jeanmougin F. Jeanmougin Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, Collège de France, Illkirch, France. Search for more papers by this author R. Losson R. Losson Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, Collège de France, Illkirch, France. Search for more papers by this author P. Chambon P. Chambon Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, Collège de France, Illkirch, France. Search for more papers by this author B. Le Douarin B. Le Douarin Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, Collège de France, Illkirch, France. Search for more papers by this author A. L. Nielsen A. L. Nielsen Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, Collège de France, Illkirch, France. Search for more papers by this author J. M. Garnier J. M. Garnier Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, Collège de France, Illkirch, France. Search for more papers by this author H. Ichinose H. Ichinose Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, Collège de France, Illkirch, France. Search for more papers by this author F. Jeanmougin F. Jeanmougin Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, Collège de France, Illkirch, France. Search for more papers by this author R. Losson R. Losson Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, Collège de France, Illkirch, France. Search for more papers by this author P. Chambon P. Chambon Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, Collège de France, Illkirch, France. Search for more papers by this author Author Information B. Le Douarin1, A. L. Nielsen1, J. M. Garnier1, H. Ichinose1, F. Jeanmougin1, R. Losson1 and P. Chambon1 1Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, Collège de France, Illkirch, France. The EMBO Journal (1996)15:6701-6715https://doi.org/10.1002/j.1460-2075.1996.tb01060.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info Nuclear receptors (NRs) are ligand-inducible transcription factors that mediate complex effects on development, differentiation and homeostasis. They regulate the transcription of their target genes through binding to cognate DNA sequences as homodimers or heterodimers. The molecular mechanisms underlying transcriptional activation by NRs are still poorly understood, although intermediary factors (mediators) appear to be involved in mediating the transactivation functions of NRs. TIF1 has been identified previously as a protein that interacts specifically with the ligand binding domain of several nuclear receptors, both in yeast and in vitro. The characteristics of these interactions have led us to suggest that TIF1 might be a mediator of the NR ligand-inducible activation function AF-2. Using a two-hybrid screening in yeast, we have now identified two TIF1-binding proteins, mHP1 alpha and mMOD1, that are mouse homologues of the Drosophila heterochromatinic protein 1. Using mHP1 alpha as a bait in a second two-hybrid screening, we have isolated cDNAs encoding proteins that are also very likely to be involved in chromatin structure and function, as well as a protein structurally and functionally related to TIF1 (renamed TIF1 alpha), which was named TIF1 beta. Here we discuss how the function of members of the TIF1 family in the control of transcription could be exerted at the level of the structure of the chromatin template. Previous ArticleNext Article Volume 15Issue 231 December 1996In this issue RelatedDetailsLoading ..." @default.
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• W1487669901 title "A possible involvement of TIF1 alpha and TIF1 beta in the epigenetic control of transcription by nuclear receptors." @default.
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