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• W1487697945 startingPage "1434" @default.
• W1487697945 abstract "Traumatic brain injury (TBI) involves diffuse axonal injury and induces subtle but persistent changes in brain tissue and function and poses challenges for early detection of neurological injury. The present study uses an automated behavioral analysis system to assess alterations in rodent behavior in the subacute phase in a preclinical mouse model of TBI, controlled cortical impact (CCI) injury. In the first few weeks following CCI, mice demonstrated normal exploratory behaviors and other typical home-cage behaviors. However, beginning 4 weeks post-injury, CCI mice developed disruptions in sleep-wake patterns, including an increased number of awakenings from sleep. Such impaired sleep maintenance was accompanied by an increased latency to reach peak sleep in CCI mice. These sleep disruptions implicate involvement of the thalamocortical network, the activity of which must be tightly regulated to control sleep maintenance. After injury, there was an increase in reactive microglia in thalamic regions as well as delayed reactive astrocytosis that was evident in the thalamic reticular nucleus, which preceded the development of sleep disruptions. These data suggest that cortical injury may trigger inflammatory responses in deeper neuroanatomical structures, including the thalamic reticular nucleus. Such engagement of the thalamus may perturb the thalamocortical network that regulates sleep/awake patterns and contribute to sleep disruptions observed in this model as well as those documented in patients with TBI." @default.
• W1487697945 created "2016-06-24" @default.
• W1487697945 creator A5058244346 @default.
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• W1487697945 date "2014-06-25" @default.
• W1487697945 modified "2023-10-05" @default.
• W1487697945 title "Delayed thalamic astrocytosis and disrupted sleep-wake patterns in a preclinical model of traumatic brain injury" @default.
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• W1487697945 doi "https://doi.org/10.1002/jnr.23430" @default.
• W1487697945 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24964253" @default.
• W1487697945 hasPublicationYear "2014" @default.
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