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- W1487703397 abstract "This chapter discusses the experimental evidence that support a pivotal role for mitochondrial dysfunction in aging. The chapter describes associative studies and an evaluation of the actual functional relevance of oxidative damage at the mitochondrial level. Oxidative damage accumulates in the mitochondrial DNA (mtDNA) (and lipids and proteins) of mice heterozygous for the mitochondrial form of superoxide dismutase (MnSOD−/+), and mitochondrial function is decreasedThere is an age-related decline in mitochondrial function culminating with elevated apoptosis. Taken together, these results suggest that oxidative damage to mitochondria is indeed associated with dysfunction and aging, and that mitochondrially induced apoptosis may be involved in the aging process. The initial observation that mitochondria are unable to remove UV-induced damage from their genomes led to the notion that mitochondria lack DNA repair capacity. The knowledge about the DNA-repair mechanisms in mitochondria is based on the identification of specific enzymes and on the studies of the repair of various lesions. Different DNA lesions are repaired through different repair pathways, and these have been identified in studies on nuclear or total DNA." @default.
- W1487703397 created "2016-06-24" @default.
- W1487703397 creator A5007515601 @default.
- W1487703397 creator A5089917586 @default.
- W1487703397 date "2002-01-01" @default.
- W1487703397 modified "2023-09-26" @default.
- W1487703397 title "The mitochondrial theory of aging: Involvement of mitochondrial DNA damage and repair" @default.
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- W1487703397 doi "https://doi.org/10.1016/s0074-7742(02)53018-x" @default.
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