FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1487904781> ?p ?o ?g. }

• W1487904781 endingPage "90" @default.
• W1487904781 startingPage "84" @default.
• W1487904781 abstract "Objective JC virus (JCV) seropositivity is a risk factor for progressive multifocal leukoencephalopathy (PML) in patients on natalizumab. Accordingly, the JCV serological antibody test is of paramount importance in determining disease risk. Methods We tested the accuracy of the JCV serum antibody test by comparing the results of JCV serology to JCV viruria and viremia in 67 patients enrolled in a single‐center, retrospective cohort study. Bodily fluids (urine and blood) were assessed for JCV DNA by real time quantitative polymerase chain reaction 6 to 47 months (mean = 26.1 months) before JCV antibody testing. In 10 individuals, blood and urine samples were obtained on 2 separate occasions at 6‐month intervals. Results Forty (59.7%) of the 67 patients were JCV seropositive. Of 27 JCV seronegative patients, 10 (37%) had JCV viruria. Urine JCV DNA copy numbers were significantly higher in the seropositive group (mean log copy number = 5.93, range = 1.85–9.21) than the seronegative group (mean log copy number = 2.41, range = 1.85–5.43; p = 0.0026). Considering all body fluid test results, 50 (74.6%) of the 67 patients were previously infected with JCV. Interpretation The false‐negative rate of the JCV serology in this study was 37%; therefore, JCV serostatus does not appear to identify all patients infected with JCV. Thus, a negative JCV antibody result should not be conflated with absence of JCV infection. This discordance may be important in understanding JCV biology, risk for PML, and PML pathogenesis. Ann Neurol 2013;74:84–90" @default.
• W1487904781 created "2016-06-24" @default.
• W1487904781 creator A5029451122 @default.
• W1487904781 creator A5055582071 @default.
• W1487904781 creator A5056869368 @default.
• W1487904781 creator A5062583822 @default.
• W1487904781 creator A5066505115 @default.
• W1487904781 creator A5087047490 @default.
• W1487904781 date "2013-07-01" @default.
• W1487904781 modified "2023-10-16" @default.
• W1487904781 title "JC virus antibody status underestimates infection rates" @default.
• W1487904781 cites W1796205141 @default.
• W1487904781 cites W1970547229 @default.
• W1487904781 cites W1978062641 @default.
• W1487904781 cites W1983511886 @default.
• W1487904781 cites W1995385281 @default.
• W1487904781 cites W1995988858 @default.
• W1487904781 cites W2000379621 @default.
• W1487904781 cites W2014795384 @default.
• W1487904781 cites W2022394389 @default.
• W1487904781 cites W2022677470 @default.
• W1487904781 cites W2028058641 @default.
• W1487904781 cites W2044022462 @default.
• W1487904781 cites W2044304191 @default.
• W1487904781 cites W2056695829 @default.
• W1487904781 cites W2060398637 @default.
• W1487904781 cites W2064922726 @default.
• W1487904781 cites W2067486972 @default.
• W1487904781 cites W2068970075 @default.
• W1487904781 cites W2069205998 @default.
• W1487904781 cites W2094159877 @default.
• W1487904781 cites W2099345484 @default.
• W1487904781 cites W2109784161 @default.
• W1487904781 cites W2118817245 @default.
• W1487904781 cites W2134781082 @default.
• W1487904781 cites W2139945560 @default.
• W1487904781 cites W2141069505 @default.
• W1487904781 cites W2142372125 @default.
• W1487904781 cites W2159032161 @default.
• W1487904781 cites W2159061752 @default.
• W1487904781 cites W2164638484 @default.
• W1487904781 cites W2169726349 @default.
• W1487904781 doi "https://doi.org/10.1002/ana.23893" @default.
• W1487904781 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3737275" @default.
• W1487904781 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23526716" @default.
• W1487904781 hasPublicationYear "2013" @default.
• W1487904781 type Work @default.
• W1487904781 sameAs 1487904781 @default.
• W1487904781 citedByCount "78" @default.
• W1487904781 countsByYear W14879047812013 @default.
• W1487904781 countsByYear W14879047812014 @default.
• W1487904781 countsByYear W14879047812015 @default.
• W1487904781 countsByYear W14879047812016 @default.
• W1487904781 countsByYear W14879047812017 @default.
• W1487904781 countsByYear W14879047812018 @default.
• W1487904781 countsByYear W14879047812019 @default.
• W1487904781 countsByYear W14879047812020 @default.
• W1487904781 countsByYear W14879047812021 @default.
• W1487904781 countsByYear W14879047812022 @default.
• W1487904781 countsByYear W14879047812023 @default.
• W1487904781 crossrefType "journal-article" @default.
• W1487904781 hasAuthorship W1487904781A5029451122 @default.
• W1487904781 hasAuthorship W1487904781A5055582071 @default.
• W1487904781 hasAuthorship W1487904781A5056869368 @default.
• W1487904781 hasAuthorship W1487904781A5062583822 @default.
• W1487904781 hasAuthorship W1487904781A5066505115 @default.
• W1487904781 hasAuthorship W1487904781A5087047490 @default.
• W1487904781 hasBestOaLocation W14879047812 @default.
• W1487904781 hasConcept C126322002 @default.
• W1487904781 hasConcept C148632171 @default.
• W1487904781 hasConcept C159047783 @default.
• W1487904781 hasConcept C159654299 @default.
• W1487904781 hasConcept C203014093 @default.
• W1487904781 hasConcept C2522874641 @default.
• W1487904781 hasConcept C2776185481 @default.
• W1487904781 hasConcept C2779150272 @default.
• W1487904781 hasConcept C2780640218 @default.
• W1487904781 hasConcept C2780644213 @default.
• W1487904781 hasConcept C2781004633 @default.
• W1487904781 hasConcept C45189115 @default.
• W1487904781 hasConcept C71924100 @default.
• W1487904781 hasConcept C86803240 @default.
• W1487904781 hasConceptScore W1487904781C126322002 @default.
• W1487904781 hasConceptScore W1487904781C148632171 @default.
• W1487904781 hasConceptScore W1487904781C159047783 @default.
• W1487904781 hasConceptScore W1487904781C159654299 @default.
• W1487904781 hasConceptScore W1487904781C203014093 @default.
• W1487904781 hasConceptScore W1487904781C2522874641 @default.
• W1487904781 hasConceptScore W1487904781C2776185481 @default.
• W1487904781 hasConceptScore W1487904781C2779150272 @default.
• W1487904781 hasConceptScore W1487904781C2780640218 @default.
• W1487904781 hasConceptScore W1487904781C2780644213 @default.
• W1487904781 hasConceptScore W1487904781C2781004633 @default.
• W1487904781 hasConceptScore W1487904781C45189115 @default.
• W1487904781 hasConceptScore W1487904781C71924100 @default.
• W1487904781 hasConceptScore W1487904781C86803240 @default.
• W1487904781 hasIssue "1" @default.
• W1487904781 hasLocation W14879047811 @default.

• next