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• W1487979560 abstract "LIF (Leukemia Inhibitory Factor) protein isolated and characterized at early 1990 as a cytokine of the IL-6 family (Williams et al., 1988; Smith et al., 1988; Gearing et al., 1989) is now one of the most popular factors used for investigations with steam cells and embryos (Nagy et al., 1993; Thomson, Marshal, 1998; Metcalf, 2003; Gonzalez et al., 2004; Paling et al., 2004; Ratajaczak et al., 2009), an a potential therapy for oncology and reproductive medicine (Kurek, 2000; Cheng et al., 2001; Gunawardana et al., 2003; Wobus, Boheler, 2005; Guney et al., 2008; Novatny et al., 2009; Aghajanova, 2010). Its molecular structure (amphiphilic protein composed mainly from hydrophobic positively charged amino acids) and molecular mechanism of its action are known in details today (Haines et al., 1999, 2000; Auernhammer, Melmed, 2000; Heinrich et al., 2003; Giese et al., 2005). As to current knowledge, LIF binds with LIF-receptor (LIF-R) of a plasma membrane and with gp130 glycoprotein, a transmembrane transporter causing activation of JAK/STAT3, MAPK and PI3P paths of intercellular transduction of a trigger signal (Hirano et al., 1997; Raz et al., 1999; Auernhammer, Melmed, 2000; Cheng et al., 2001; Park et al., 2003; Paling et al., 2004; Gonzalez et al., 2004; Boniani, Scholer, 2005). Targets genes activated by these signal systems response for proliferation, apoptosis, cell cycles and differentiation. Acting appropriate receptor complexes (LIF-R-gp130), LIF may cause various cell reactions. In mouse embryonic stem cells (ESC) it blocks processes of spontaneous differentiation and formation of embryoid bodies (EB, analogs of early mammal embryos) maintaining thus the stem cells in pluripotent state in vitro (Gearing et al., 1989; Raz et al., 1999; Nagy et al., 1993; Thomson, Marshal, 1998; Wobus, Boheler, 2005). High dependence of mouse ESC lines from LIF is evidenced by the fact that at a LIF-free culture medium the cells spontaneously differentiate into EB loosing thus their pluripotent properties. Main mechanisms of LIF effects, through cell membrane receptors, are comprehensively investigated (Haines et al., 1999, 2000; Heinrich et al., 2003; Gonzalez et al., 2004; Giese et al., 2005) and widely" @default.
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• W1487979560 date "2011-04-26" @default.
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• W1487979560 title "Effects of Recombinant Leukemia Inhibitory Factor (LIF) on Functional Status of Mouse Embryonic Stem Cells" @default.
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• W1487979560 doi "https://doi.org/10.5772/14674" @default.
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