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- W1488045452 abstract "Publisher Summary This chapter focuses on the role of quinoids in the DNA damage induced by estrogens and antiestrogen metabolites. Selective estrogen receptor modulators (SERMs) are developed for the treatment of menopause-associated osteoporosis, with a primary application being in the treatment and prevention of breast cancer in postmenopausal women. The most widely used SERM is tamoxifen, which is extensively used for the treatment of hormone-dependent breast cancer and more recently as a chemopreventive agent in women at risk for breast cancer; however, like the estrogens associated with estrogen replacement therapy, tamoxifen can also lead to an increased endometrial cancer risk. The molecular mechanism(s) involved in the carcinogenic action of estrogens and antiestrogens still remains both controversial and elusive. Both can be metabolized to reactive intermediates such as o-quinones and quinone methides, which could cause DNA damage directly through the formation of DNA adducts or indirectly through the generation of reactive oxygen species that oxidize DNA. It is shown that quinones and quinone methides can be formed from both estrogens and antiestrogens. These reactive species can cause damage in cells either through alkylation of cellular macromolecules and/or through generation of reactive oxygen species." @default.
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- W1488045452 date "2004-01-01" @default.
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- W1488045452 title "Quinoids Formed from Estrogens and Antiestrogens" @default.
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- W1488045452 doi "https://doi.org/10.1016/s0076-6879(04)78006-4" @default.
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