FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1488134098> ?p ?o ?g. }

• W1488134098 endingPage "3608" @default.
• W1488134098 startingPage "3597" @default.
• W1488134098 abstract "Abstract T cell homeostasis is crucial for maintaining an efficient and balanced T cell immunity. The interaction between TCR and self peptide (sp) MHC ligands is known to be the key driving force in this process, and it is believed to be functionally and mechanistically different from that initiated by the antigenic TCR stimulation. Yet, very little is known about the downstream signaling events triggered by this TCR-spMHC interaction and how they differ from those triggered by antigenic TCR stimulation. In this study, we show that T cell conditional ablation of MEKK3, a Ser/Thr kinase in the MAPK cascade, causes a significant reduction in peripheral T cell numbers in the conditional knockout mice, but does not perturb thymic T cell development and maturation. Using an adoptive mixed transfer method, we show that MEKK3-deficient T cells are severely impaired in lymphopenia-induced cell proliferation and survival. Interestingly, the Ag-induced T cell proliferation proceeds normally in the absence of MEKK3. Finally, we found that the activity of ERK1/2, but not p38 MAPK, was attenuated during the lymphopenia-driven response in MEKK3-deficient T cells. Together, these data suggest that MEKK3 may play a crucial selective role for spMHC-mediated T cell homeostasis." @default.
• W1488134098 created "2016-06-24" @default.
• W1488134098 creator A5001262815 @default.
• W1488134098 creator A5024756660 @default.
• W1488134098 creator A5071030446 @default.
• W1488134098 creator A5072050974 @default.
• W1488134098 creator A5073048001 @default.
• W1488134098 date "2009-03-15" @default.
• W1488134098 modified "2023-10-18" @default.
• W1488134098 title "MEKK3 Is Essential for Lymphopenia-Induced T Cell Proliferation and Survival" @default.
• W1488134098 cites W101423292 @default.
• W1488134098 cites W1508676807 @default.
• W1488134098 cites W1509142888 @default.
• W1488134098 cites W1509514214 @default.
• W1488134098 cites W1519531812 @default.
• W1488134098 cites W1532865172 @default.
• W1488134098 cites W1558376983 @default.
• W1488134098 cites W1595687567 @default.
• W1488134098 cites W1601504908 @default.
• W1488134098 cites W1666984035 @default.
• W1488134098 cites W1699053637 @default.
• W1488134098 cites W1893260165 @default.
• W1488134098 cites W1964456603 @default.
• W1488134098 cites W1966432380 @default.
• W1488134098 cites W1967015219 @default.
• W1488134098 cites W1987536174 @default.
• W1488134098 cites W1992031335 @default.
• W1488134098 cites W1993928278 @default.
• W1488134098 cites W1996405087 @default.
• W1488134098 cites W1996635688 @default.
• W1488134098 cites W2000525428 @default.
• W1488134098 cites W2003850151 @default.
• W1488134098 cites W2009213488 @default.
• W1488134098 cites W2009667315 @default.
• W1488134098 cites W2010489503 @default.
• W1488134098 cites W2016852033 @default.
• W1488134098 cites W2018947464 @default.
• W1488134098 cites W2022217630 @default.
• W1488134098 cites W2030174965 @default.
• W1488134098 cites W2032582358 @default.
• W1488134098 cites W2040370363 @default.
• W1488134098 cites W2041782793 @default.
• W1488134098 cites W2042216100 @default.
• W1488134098 cites W2042450205 @default.
• W1488134098 cites W2049115432 @default.
• W1488134098 cites W2053894639 @default.
• W1488134098 cites W2060630008 @default.
• W1488134098 cites W2063501226 @default.
• W1488134098 cites W2070380446 @default.
• W1488134098 cites W2074321172 @default.
• W1488134098 cites W2085555998 @default.
• W1488134098 cites W2095938345 @default.
• W1488134098 cites W2101422485 @default.
• W1488134098 cites W2108819594 @default.
• W1488134098 cites W2109627278 @default.
• W1488134098 cites W2111252945 @default.
• W1488134098 cites W2116688247 @default.
• W1488134098 cites W2144526849 @default.
• W1488134098 cites W2145933283 @default.
• W1488134098 cites W2148047471 @default.
• W1488134098 cites W2158969445 @default.
• W1488134098 cites W2159660733 @default.
• W1488134098 cites W2163955606 @default.
• W1488134098 cites W2166676682 @default.
• W1488134098 cites W4210255498 @default.
• W1488134098 cites W4211059834 @default.
• W1488134098 cites W4230055812 @default.
• W1488134098 cites W2034524378 @default.
• W1488134098 doi "https://doi.org/10.4049/jimmunol.0803738" @default.
• W1488134098 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2923428" @default.
• W1488134098 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19265138" @default.
• W1488134098 hasPublicationYear "2009" @default.
• W1488134098 type Work @default.
• W1488134098 sameAs 1488134098 @default.
• W1488134098 citedByCount "19" @default.
• W1488134098 countsByYear W14881340982012 @default.
• W1488134098 countsByYear W14881340982013 @default.
• W1488134098 countsByYear W14881340982015 @default.
• W1488134098 countsByYear W14881340982018 @default.
• W1488134098 countsByYear W14881340982021 @default.
• W1488134098 countsByYear W14881340982022 @default.
• W1488134098 countsByYear W14881340982023 @default.
• W1488134098 crossrefType "journal-article" @default.
• W1488134098 hasAuthorship W1488134098A5001262815 @default.
• W1488134098 hasAuthorship W1488134098A5024756660 @default.
• W1488134098 hasAuthorship W1488134098A5071030446 @default.
• W1488134098 hasAuthorship W1488134098A5072050974 @default.
• W1488134098 hasAuthorship W1488134098A5073048001 @default.
• W1488134098 hasBestOaLocation W14881340981 @default.
• W1488134098 hasConcept C104317684 @default.
• W1488134098 hasConcept C127716648 @default.
• W1488134098 hasConcept C147483822 @default.
• W1488134098 hasConcept C148125776 @default.
• W1488134098 hasConcept C1491633281 @default.
• W1488134098 hasConcept C164659718 @default.
• W1488134098 hasConcept C19317047 @default.
• W1488134098 hasConcept C203014093 @default.
• W1488134098 hasConcept C2776090121 @default.

• next