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• W1488161640 endingPage "457" @default.
• W1488161640 startingPage "443" @default.
• W1488161640 abstract "Cerebellar Purkinje cells integrate motor information conveyed by excitatory synaptic inputs from parallel and climbing fibres. Purkinje cells abundantly express B‐type G‐protein‐coupled γ‐aminobutyric acid receptors (GABA B R) that are assumed to mediate major responses, including postsynaptic modulation of the synaptic inputs. However, the identity and function of effectors operated by GABA B R are not fully elucidated. Here we characterized an inwardly rectifying current activated by baclofen ( I bacl ), a GABA B R agonist, in cultured mouse Purkinje cells using a ruptured‐patch whole‐cell technique. I bacl is operated by GABA B R via G i/o ‐proteins, as it is not inducible in pertussis‐toxin‐pretreated cells. I bacl is carried by K + because its reversal potential shifts with the equilibrium potential of K + . I bacl is blocked by 10 −3 m Ba 2+ or Cs + , and 10 −8 m tertiapin‐Q. Upon the onset and offset of a hyperpolarizing step, I bacl is activated and deactivated, respectively, with double‐exponential time courses (time constants, <1 ms and 30–80 ms). Based on similarities in the above properties, G‐protein‐coupled inwardly rectifying K + (GIRK) channels are thought to be responsible for I bacl . Perforated‐patch recordings from cultured Purkinje cells demonstrate that I bacl hyperpolarizes the resting potential and the peak level achieved by glutamate‐evoked potentials initiated in the dendrites. Moreover, cell‐attached recordings from Purkinje cells in cerebellar slices demonstrate that I bacl impedes spontaneous firing. Therefore, I bacl may reduce the postsynaptic and intrinsic excitability of Purkinje cells under physiological conditions. These findings give a new insight into the role of GABA B R signalling in cerebellar information processing." @default.
• W1488161640 created "2016-06-24" @default.
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• W1488161640 date "2005-02-21" @default.
• W1488161640 modified "2023-10-15" @default.
• W1488161640 title "GABAergic activation of an inwardly rectifying K⁺current in mouse cerebellar Purkinje cells" @default.
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• W1488161640 doi "https://doi.org/10.1113/jphysiol.2004.081000" @default.
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