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• W148817265 abstract "Research Article1 May 1990free access A Go-like protein in Drosophila melanogaster and its expression in memory mutants. A. Guillén A. Guillén Centre CNRS-INSERM de Pharmacologie-Endocrinologie, Montpellier, France. Search for more papers by this author J.M. Jallon J.M. Jallon Centre CNRS-INSERM de Pharmacologie-Endocrinologie, Montpellier, France. Search for more papers by this author J.A. Fehrentz J.A. Fehrentz Centre CNRS-INSERM de Pharmacologie-Endocrinologie, Montpellier, France. Search for more papers by this author C. Pantaloni C. Pantaloni Centre CNRS-INSERM de Pharmacologie-Endocrinologie, Montpellier, France. Search for more papers by this author J. Bockaert J. Bockaert Centre CNRS-INSERM de Pharmacologie-Endocrinologie, Montpellier, France. Search for more papers by this author V. Homburger V. Homburger Centre CNRS-INSERM de Pharmacologie-Endocrinologie, Montpellier, France. Search for more papers by this author A. Guillén A. Guillén Centre CNRS-INSERM de Pharmacologie-Endocrinologie, Montpellier, France. Search for more papers by this author J.M. Jallon J.M. Jallon Centre CNRS-INSERM de Pharmacologie-Endocrinologie, Montpellier, France. Search for more papers by this author J.A. Fehrentz J.A. Fehrentz Centre CNRS-INSERM de Pharmacologie-Endocrinologie, Montpellier, France. Search for more papers by this author C. Pantaloni C. Pantaloni Centre CNRS-INSERM de Pharmacologie-Endocrinologie, Montpellier, France. Search for more papers by this author J. Bockaert J. Bockaert Centre CNRS-INSERM de Pharmacologie-Endocrinologie, Montpellier, France. Search for more papers by this author V. Homburger V. Homburger Centre CNRS-INSERM de Pharmacologie-Endocrinologie, Montpellier, France. Search for more papers by this author Author Information A. Guillén1, J.M. Jallon1, J.A. Fehrentz1, C. Pantaloni1, J. Bockaert1 and V. Homburger1 1Centre CNRS-INSERM de Pharmacologie-Endocrinologie, Montpellier, France. The EMBO Journal (1990)9:1449-1455https://doi.org/10.1002/j.1460-2075.1990.tb08261.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info G proteins couple receptors for extracellular signals to several intracellular effector systems and play a key role in signalling transduction mechanisms. In particulate preparations of Drosophila melanogaster heads, only one substrate for pertussis toxin at 39-40 kd was detected. This substrate, which showed only one isoform when analysed by isoelectric focusing, was recognized by immunoblotting and immunoprecipitation techniques using a polyclonal antibody against the alpha subunit of the Go protein purified from bovine brain and can be thus considered as a Go-like protein. Antibodies obtained against a carboxy-terminal sequence of the alpha subunit of Go (but not of Gi1 or Gi2) and against an internal sequence shared by all the alpha subunits, were also able to cross-react with the alpha subunit of this protein in insects. We have also studied the Go-like protein in several D.melanogaster mutants, primarily in memory and learning mutants. In these mutants there was a sex-dependent enhancement in pertussis toxin-catalysed ADP-ribosylation with respect to the wild-type. This increase could be attributed in part to an increase in the alpha subunit of the Go-like protein, as revealed by immunoblotting with anti-Go alpha polyclonal antibody. This report constitutes the first evidence for the participation of a Go protein in learning and memory. Previous ArticleNext Article Volume 9Issue 51 May 1990In this issue RelatedDetailsLoading ..." @default.
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• W148817265 date "1990-05-01" @default.
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• W148817265 title "A Go-like protein in Drosophila melanogaster and its expression in memory mutants." @default.
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