Matches in SemOpenAlex for { <https://semopenalex.org/work/W1488213621> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W1488213621 abstract "Lung cancer has the highest mortality rate of all of the cancers in the world and asbestos-related lung cancer is one of the leading occupational cancers. The identification of asbestos-related molecular changes has long been a topic of increasing research interest. Microarray technology is a powerful high-throughput tool capable of monitoring the expression of thousands of small noncoding RNAs at once within tens of samples processed in parallel in a single experiment. The aim of this study was to construct a genome-wide expression profile of miRNA of asbestos-related lung cancers, and was to identify novel asbestos-related molecular biomarkers. The miRNA profiling was performed on 31 patients (13 patients with asbestos-exposed and 18 patients with non- asbestos-exposed) undergoing lung resection for primary adenocarcinoma, both fresh and FFPE materials of whom were available. Data analyses on miRNA expression revealed four novel asbestos-related miRNAs (three over-expressed miR-210, miR-200a, miR-429, and one under-expressed miR-140-3p). Also, 16 target genes, expression of which were inversely correlated, were identified. Among them we obtained a set of miRNAs that were involved in hypoxia-regulated and oxidative stress responders, seemingly related to asbestos burden. For example, miR-210 is involved in a wide-range of processes, including cell proliferation, migration, apoptosis, differentiation, DNA repair and cell metabolism, and more recently in the regulation of antitumor immune responses, suggesting roles of this miRNA as a central master regulator of the hypoxic response. According to gene ontology analyses of the target genes were mostly transcription factors, cyclins and cyclin-dependent kinases. For validation, we compared the expression levels of miRNA between fresh and FFPE materials, resulting in good correlations (R=0.76-0.90). The miRNAs/genes presented here may be interesting targets for further investigation and could eventually have potential diagnostic implications. Citation Format: Yasen Mahmut, Hironori Ninomiya, Noriko Motoi, Satoru Itoh, Mutsunori Fujiwara, Yuichi Ishikawa. Expression profiling of miRNA in asbestos-related lung adenocarcinoma. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 300. doi:10.1158/1538-7445.AM2014-300" @default.
- W1488213621 created "2016-06-24" @default.
- W1488213621 creator A5007635404 @default.
- W1488213621 creator A5036422444 @default.
- W1488213621 creator A5041853152 @default.
- W1488213621 creator A5050646209 @default.
- W1488213621 creator A5063211344 @default.
- W1488213621 creator A5065163666 @default.
- W1488213621 date "2014-09-30" @default.
- W1488213621 modified "2023-09-30" @default.
- W1488213621 title "Abstract 300: Expression profiling of miRNA in asbestos-related lung adenocarcinoma" @default.
- W1488213621 doi "https://doi.org/10.1158/1538-7445.am2014-300" @default.
- W1488213621 hasPublicationYear "2014" @default.
- W1488213621 type Work @default.
- W1488213621 sameAs 1488213621 @default.
- W1488213621 citedByCount "0" @default.
- W1488213621 crossrefType "proceedings-article" @default.
- W1488213621 hasAuthorship W1488213621A5007635404 @default.
- W1488213621 hasAuthorship W1488213621A5036422444 @default.
- W1488213621 hasAuthorship W1488213621A5041853152 @default.
- W1488213621 hasAuthorship W1488213621A5050646209 @default.
- W1488213621 hasAuthorship W1488213621A5063211344 @default.
- W1488213621 hasAuthorship W1488213621A5065163666 @default.
- W1488213621 hasConcept C104317684 @default.
- W1488213621 hasConcept C121608353 @default.
- W1488213621 hasConcept C142724271 @default.
- W1488213621 hasConcept C143998085 @default.
- W1488213621 hasConcept C145059251 @default.
- W1488213621 hasConcept C150194340 @default.
- W1488213621 hasConcept C18431079 @default.
- W1488213621 hasConcept C186836561 @default.
- W1488213621 hasConcept C191897082 @default.
- W1488213621 hasConcept C192562407 @default.
- W1488213621 hasConcept C2776256026 @default.
- W1488213621 hasConcept C2777407522 @default.
- W1488213621 hasConcept C2781182431 @default.
- W1488213621 hasConcept C502942594 @default.
- W1488213621 hasConcept C510490043 @default.
- W1488213621 hasConcept C54355233 @default.
- W1488213621 hasConcept C60644358 @default.
- W1488213621 hasConcept C70721500 @default.
- W1488213621 hasConcept C71924100 @default.
- W1488213621 hasConcept C86803240 @default.
- W1488213621 hasConceptScore W1488213621C104317684 @default.
- W1488213621 hasConceptScore W1488213621C121608353 @default.
- W1488213621 hasConceptScore W1488213621C142724271 @default.
- W1488213621 hasConceptScore W1488213621C143998085 @default.
- W1488213621 hasConceptScore W1488213621C145059251 @default.
- W1488213621 hasConceptScore W1488213621C150194340 @default.
- W1488213621 hasConceptScore W1488213621C18431079 @default.
- W1488213621 hasConceptScore W1488213621C186836561 @default.
- W1488213621 hasConceptScore W1488213621C191897082 @default.
- W1488213621 hasConceptScore W1488213621C192562407 @default.
- W1488213621 hasConceptScore W1488213621C2776256026 @default.
- W1488213621 hasConceptScore W1488213621C2777407522 @default.
- W1488213621 hasConceptScore W1488213621C2781182431 @default.
- W1488213621 hasConceptScore W1488213621C502942594 @default.
- W1488213621 hasConceptScore W1488213621C510490043 @default.
- W1488213621 hasConceptScore W1488213621C54355233 @default.
- W1488213621 hasConceptScore W1488213621C60644358 @default.
- W1488213621 hasConceptScore W1488213621C70721500 @default.
- W1488213621 hasConceptScore W1488213621C71924100 @default.
- W1488213621 hasConceptScore W1488213621C86803240 @default.
- W1488213621 hasLocation W14882136211 @default.
- W1488213621 hasOpenAccess W1488213621 @default.
- W1488213621 hasPrimaryLocation W14882136211 @default.
- W1488213621 hasRelatedWork W1939662637 @default.
- W1488213621 hasRelatedWork W1978019837 @default.
- W1488213621 hasRelatedWork W1996782413 @default.
- W1488213621 hasRelatedWork W2032764202 @default.
- W1488213621 hasRelatedWork W2075608631 @default.
- W1488213621 hasRelatedWork W2118352309 @default.
- W1488213621 hasRelatedWork W2167835371 @default.
- W1488213621 hasRelatedWork W2171812488 @default.
- W1488213621 hasRelatedWork W2315721214 @default.
- W1488213621 hasRelatedWork W2317548946 @default.
- W1488213621 hasRelatedWork W2318162454 @default.
- W1488213621 hasRelatedWork W2334235309 @default.
- W1488213621 hasRelatedWork W2338137842 @default.
- W1488213621 hasRelatedWork W2340381364 @default.
- W1488213621 hasRelatedWork W2475162112 @default.
- W1488213621 hasRelatedWork W2567026559 @default.
- W1488213621 hasRelatedWork W2617032619 @default.
- W1488213621 hasRelatedWork W2922867834 @default.
- W1488213621 hasRelatedWork W2952454785 @default.
- W1488213621 hasRelatedWork W2182348285 @default.
- W1488213621 isParatext "false" @default.
- W1488213621 isRetracted "false" @default.
- W1488213621 magId "1488213621" @default.
- W1488213621 workType "article" @default.