Matches in SemOpenAlex for { <https://semopenalex.org/work/W1488257841> ?p ?o ?g. }
- W1488257841 endingPage "376" @default.
- W1488257841 startingPage "362" @default.
- W1488257841 abstract "Discoveries of the cardiac natriuretic peptides ANP, BNP, and CNP along with studies of their function and regulation in health and disease, have led to breakthroughs in the understanding and clinical management of heart failure. Analysis of the ANP and BNP promoters and patterns of expression uncovered a set of key regulators and pathways that converge onto these sensitive markers of early myocyte differentiation and cardiac stress. Among the most studied are the transcription factors GATA4, TBX5, and NKX2-5, which are central to cardiac development and mutations of which are associated with congenital heart disease. In clinical practice, plasma natriuretic peptides levels have been used as quantitative biomarkers of heart failure and proved to be highly effective for the diagnosis of heart failure, for risk-stratification of patients and guided therapy, as well as for screening for subclinical cardiac stress. Emerging studies are revealing the cardioprotective attributes of these peptides and may offer new therapeutic venues for myocardial infarction and heart failure. Clinical trials have documented the benefits and risks of the use of synthetic ANP (Anaritide) and BNP (Nesiritide) for treating heart failure, renal failure, and hypertension. This review summarizes the function and regulation of cardiac natriuretic peptides and the translation of the basic biochemical discoveries into clinical practice both at the diagnostic and therapeutic level." @default.
- W1488257841 created "2016-06-24" @default.
- W1488257841 creator A5004454600 @default.
- W1488257841 creator A5084303286 @default.
- W1488257841 date "2010-04-23" @default.
- W1488257841 modified "2023-09-30" @default.
- W1488257841 title "Cardiac Natriuretic Peptides: From Basic Discovery to Clinical Practice" @default.
- W1488257841 cites W1489316903 @default.
- W1488257841 cites W1491435711 @default.
- W1488257841 cites W1545907965 @default.
- W1488257841 cites W1546454746 @default.
- W1488257841 cites W1553668020 @default.
- W1488257841 cites W1591880706 @default.
- W1488257841 cites W1847353603 @default.
- W1488257841 cites W1901586851 @default.
- W1488257841 cites W1912249044 @default.
- W1488257841 cites W1956857062 @default.
- W1488257841 cites W1963713784 @default.
- W1488257841 cites W1969677127 @default.
- W1488257841 cites W1971321746 @default.
- W1488257841 cites W1973431915 @default.
- W1488257841 cites W1973524855 @default.
- W1488257841 cites W1975971363 @default.
- W1488257841 cites W1976110338 @default.
- W1488257841 cites W1978162225 @default.
- W1488257841 cites W1979381258 @default.
- W1488257841 cites W1981197421 @default.
- W1488257841 cites W1981423323 @default.
- W1488257841 cites W1981438457 @default.
- W1488257841 cites W1984092953 @default.
- W1488257841 cites W1984617425 @default.
- W1488257841 cites W1984893737 @default.
- W1488257841 cites W1985126965 @default.
- W1488257841 cites W1985951474 @default.
- W1488257841 cites W1986114415 @default.
- W1488257841 cites W1986819632 @default.
- W1488257841 cites W1988232724 @default.
- W1488257841 cites W1988816170 @default.
- W1488257841 cites W1993577260 @default.
- W1488257841 cites W1998139028 @default.
- W1488257841 cites W2000526551 @default.
- W1488257841 cites W2001637044 @default.
- W1488257841 cites W2001875144 @default.
- W1488257841 cites W2004717923 @default.
- W1488257841 cites W2009572451 @default.
- W1488257841 cites W2011632934 @default.
- W1488257841 cites W2011780678 @default.
- W1488257841 cites W2011920764 @default.
- W1488257841 cites W2013933388 @default.
- W1488257841 cites W2014371208 @default.
- W1488257841 cites W2015588606 @default.
- W1488257841 cites W2015853348 @default.
- W1488257841 cites W2016476207 @default.
- W1488257841 cites W2016870770 @default.
- W1488257841 cites W2017557087 @default.
- W1488257841 cites W2018892038 @default.
- W1488257841 cites W2019530341 @default.
- W1488257841 cites W2020140879 @default.
- W1488257841 cites W2020684464 @default.
- W1488257841 cites W2024505897 @default.
- W1488257841 cites W2027314542 @default.
- W1488257841 cites W2027764827 @default.
- W1488257841 cites W2027792004 @default.
- W1488257841 cites W2029253480 @default.
- W1488257841 cites W2030165232 @default.
- W1488257841 cites W2034178790 @default.
- W1488257841 cites W2036929209 @default.
- W1488257841 cites W2037761331 @default.
- W1488257841 cites W2038254709 @default.
- W1488257841 cites W2040686597 @default.
- W1488257841 cites W2043463661 @default.
- W1488257841 cites W2045076976 @default.
- W1488257841 cites W2047866697 @default.
- W1488257841 cites W2049783720 @default.
- W1488257841 cites W2050897511 @default.
- W1488257841 cites W2052097767 @default.
- W1488257841 cites W2052201968 @default.
- W1488257841 cites W2053234324 @default.
- W1488257841 cites W2053348556 @default.
- W1488257841 cites W2058218983 @default.
- W1488257841 cites W2059535615 @default.
- W1488257841 cites W2059624079 @default.
- W1488257841 cites W2064586774 @default.
- W1488257841 cites W2065756643 @default.
- W1488257841 cites W2066318206 @default.
- W1488257841 cites W2069058209 @default.
- W1488257841 cites W2071443658 @default.
- W1488257841 cites W2073860278 @default.
- W1488257841 cites W2074862244 @default.
- W1488257841 cites W2076234410 @default.
- W1488257841 cites W2076600697 @default.
- W1488257841 cites W2079577417 @default.
- W1488257841 cites W2079686275 @default.
- W1488257841 cites W2083009193 @default.
- W1488257841 cites W2084077120 @default.
- W1488257841 cites W2090255087 @default.
- W1488257841 cites W2092244785 @default.
- W1488257841 cites W2093695309 @default.