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- W1488286018 abstract "microRNA异常表达促进癌症的发生发展. 本研究通过microRNA表达谱分析2个肝癌细胞和2个正常细胞microRNA的表达, 寻找与肝癌相关的microRNA, 发现 microRNA-215 在肝癌细胞中高表达, qRT-PCR验证 microRNA-215 在肝癌细胞呈显著高表达. 进一步研究发现, microRNA-215 直接靶向 Dicer1 基因的3'UTR并抑制Dicer1蛋白表达, Dicer1是microRNA加工成熟过程中必需的蛋白. 过表达 microRNA-215 抑制Dicer1从而促进肝癌细胞迁移和转化, 而抑制 microRNA-215 表达起相反作用. Dicer1抑制后, 许多抑癌microRNA表达被抑制, 从而促进迁移和转化. 相对于癌旁组织, Dicer1在肝癌组织呈明显低表达. 本研究揭示, microRNA-215 异常活化并抑制Dicer1表达与肝癌发展相关." @default.
- W1488286018 created "2016-06-24" @default.
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- W1488286018 date "2015-02-01" @default.
- W1488286018 modified "2023-09-23" @default.
- W1488286018 title "Aberrant Activation of <italic>MicroRNA-215</italic> Promotes Hepatocellular Carcinoma Cell Migration and Transformation through Directly Inhibiting Dicer1" @default.
- W1488286018 doi "https://doi.org/10.1360/n052014-00302" @default.
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