FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1488335717> ?p ?o ?g. }

• W1488335717 endingPage "4961" @default.
• W1488335717 startingPage "4954" @default.
• W1488335717 abstract "Synapse elimination is considered to be the final step in neural circuit formation, by causing refinement of redundant connections formed at earlier developmental stages. The developmental loss of climbing fiber innervation from cerebellar Purkinje cells is an example of such synapse elimination. It has been suggested that NMDA receptors are involved in the elimination of climbing fiber synapses. In the present study, we probed the NMDA receptor-dependent period of climbing fiber synapse elimination by using daily intraperitoneal injections of the NMDA receptor antagonist MK-801. We found that blockade of NMDA receptors during postnatal day 15 (P15) and P16, but not before or after this period, resulted in a higher incidence of multiple climbing fiber innervation and caused a mild but persistent loss of motor coordination. Neither basic synaptic functions nor cerebellar morphology were affected by this manipulation. Chronic local application of MK-801 to the cerebellum during P15 and P16 also yielded a higher incidence of multiple climbing fiber innervation. During P15–P16, large NMDA receptor-mediated EPSCs were detected at the mossy fiber–granule cell synapse, but not at the parallel fiber–Purkinje cell or climbing fiber–Purkinje cell synapse. It is therefore likely that the NMDA receptors located at the mossy fiber–granule cell synapse mediate signals leading to the elimination of surplus climbing fibers. These results suggest that an NMDA receptor-dependent phase of climbing fiber synapse elimination lasts 2 d at most. During this phase, the final refinement of climbing fiber synapses occurs, and disruption of this process leads to permanent impairment of cerebellar function." @default.
• W1488335717 created "2016-06-24" @default.
• W1488335717 creator A5004433934 @default.
• W1488335717 creator A5014297179 @default.
• W1488335717 creator A5017811687 @default.
• W1488335717 creator A5072607053 @default.
• W1488335717 date "2000-07-01" @default.
• W1488335717 modified "2023-10-12" @default.
• W1488335717 title "Critical Period for Activity-Dependent Synapse Elimination in Developing Cerebellum" @default.
• W1488335717 cites W1534586962 @default.
• W1488335717 cites W1585949905 @default.
• W1488335717 cites W1667361580 @default.
• W1488335717 cites W1842266333 @default.
• W1488335717 cites W1963806203 @default.
• W1488335717 cites W1963989698 @default.
• W1488335717 cites W1972675325 @default.
• W1488335717 cites W1975522748 @default.
• W1488335717 cites W1979996083 @default.
• W1488335717 cites W1980261326 @default.
• W1488335717 cites W1981416398 @default.
• W1488335717 cites W1983695135 @default.
• W1488335717 cites W1989670552 @default.
• W1488335717 cites W1990831527 @default.
• W1488335717 cites W1992613763 @default.
• W1488335717 cites W1995679813 @default.
• W1488335717 cites W1996805443 @default.
• W1488335717 cites W1996892917 @default.
• W1488335717 cites W2010101907 @default.
• W1488335717 cites W2019742983 @default.
• W1488335717 cites W2022644200 @default.
• W1488335717 cites W2024467572 @default.
• W1488335717 cites W2026022097 @default.
• W1488335717 cites W2038789827 @default.
• W1488335717 cites W2050419480 @default.
• W1488335717 cites W2052839330 @default.
• W1488335717 cites W2053148425 @default.
• W1488335717 cites W2053213696 @default.
• W1488335717 cites W2060601033 @default.
• W1488335717 cites W2060966417 @default.
• W1488335717 cites W2066439205 @default.
• W1488335717 cites W2074071827 @default.
• W1488335717 cites W2074414687 @default.
• W1488335717 cites W2074683128 @default.
• W1488335717 cites W2077178218 @default.
• W1488335717 cites W2077211332 @default.
• W1488335717 cites W2080994299 @default.
• W1488335717 cites W2086143132 @default.
• W1488335717 cites W2087459771 @default.
• W1488335717 cites W2089392743 @default.
• W1488335717 cites W2101347364 @default.
• W1488335717 cites W2106977035 @default.
• W1488335717 cites W2112834623 @default.
• W1488335717 cites W2120954774 @default.
• W1488335717 cites W2123343810 @default.
• W1488335717 cites W2128645913 @default.
• W1488335717 cites W2129344306 @default.
• W1488335717 cites W2140439285 @default.
• W1488335717 cites W2151518651 @default.
• W1488335717 cites W2153315387 @default.
• W1488335717 cites W2170428391 @default.
• W1488335717 cites W2170576424 @default.
• W1488335717 cites W2171370311 @default.
• W1488335717 cites W4293416615 @default.
• W1488335717 doi "https://doi.org/10.1523/jneurosci.20-13-04954.2000" @default.
• W1488335717 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6772278" @default.
• W1488335717 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10864953" @default.
• W1488335717 hasPublicationYear "2000" @default.
• W1488335717 type Work @default.
• W1488335717 sameAs 1488335717 @default.
• W1488335717 citedByCount "170" @default.
• W1488335717 countsByYear W14883357172012 @default.
• W1488335717 countsByYear W14883357172013 @default.
• W1488335717 countsByYear W14883357172014 @default.
• W1488335717 countsByYear W14883357172015 @default.
• W1488335717 countsByYear W14883357172016 @default.
• W1488335717 countsByYear W14883357172017 @default.
• W1488335717 countsByYear W14883357172018 @default.
• W1488335717 countsByYear W14883357172019 @default.
• W1488335717 countsByYear W14883357172020 @default.
• W1488335717 countsByYear W14883357172021 @default.
• W1488335717 countsByYear W14883357172022 @default.
• W1488335717 crossrefType "journal-article" @default.
• W1488335717 hasAuthorship W1488335717A5004433934 @default.
• W1488335717 hasAuthorship W1488335717A5014297179 @default.
• W1488335717 hasAuthorship W1488335717A5017811687 @default.
• W1488335717 hasAuthorship W1488335717A5072607053 @default.
• W1488335717 hasBestOaLocation W14883357171 @default.
• W1488335717 hasConcept C127445978 @default.
• W1488335717 hasConcept C169760540 @default.
• W1488335717 hasConcept C170493617 @default.
• W1488335717 hasConcept C185592680 @default.
• W1488335717 hasConcept C18903297 @default.
• W1488335717 hasConcept C2776464000 @default.
• W1488335717 hasConcept C2778058767 @default.
• W1488335717 hasConcept C2778472085 @default.
• W1488335717 hasConcept C2778888523 @default.
• W1488335717 hasConcept C2779652256 @default.
• W1488335717 hasConcept C2780393176 @default.

• next