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• W1488395817 abstract "Evidence related to the influence of dietary fiber on cardiovascular disease in man is epidemiological in nature. Indeed, in the absence of an ante mortem test for the impending event, all dietary and environmental factors correlated with the incidence of heart disease are regarded as risk factors and represent statistical rather than medical diagnoses, albeit some correlations are highly significant. Experimental atherosclerosis provides a more direct test of hypotheses, but the disease does not always resemble human disease. The field of experimental atherosclerosis has not defined the ideal animal model. Work is now being carried out in primates, swine, rabbits, and birds, with each model having advantages and drawbacks. Animal studies with fiber must be examined in the light of suitability of a particular species for atherosclerosis research. Data derived from human or animal studies represent work done with a mixed diet whose total fiber content can be determined or with specific materials such as bran, alfalfa, cellulose, and pectin. We could regard the components of a mixed diet as the natural form of ingested fiber, whereas specific purifled materials (such as pectin) or materials that may vary from sample to sample (such as alfalfa or bran) could be thought of as therapeutic dietary additives. The principal problem involves identification ofthe specific component of fiber responsible for the observed results. We will also need to learn if fiber extracted from a foodstuff functions as it does in the natural state, in situ as it were. We need better data on the composition of fiber present in the general diet; this calls for a standardized analytic methodology. We will then be in a position to assess the mode(s) of action of cellulose, hemicellulose, pectin, hgnm, and gums and to determine the synergistic or antagonistic relationships among them. The effects of dietary fiber are part of the digestive process and, as such, represent a continuous dynamic process. Current work involves application of parameters of equihibrium systems to this process. Perhaps our perceptions of how fiber works should be altered. It may be that a biological as well as a chemical definition of fiber may be required." @default.
• W1488395817 created "2016-06-24" @default.
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• W1488395817 date "1978-10-01" @default.
• W1488395817 modified "2023-09-25" @default.
• W1488395817 title "Workshop IV—Fiber, lipids, and cardiovascular disease Summary and recommendations" @default.
• W1488395817 doi "https://doi.org/10.1093/ajcn/31.10.s190" @default.
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