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• W1488397830 abstract "3T3 cells transformed with a thermosensitive mutant of polyoma (Ts-a) can be induced to produce virus if the cells (Ts-a-3T3) are transferred from 38.5 °C to 31 °C (Vogt, 1970). Viral DNA synthesis is detectable in the activated cell population 24 hours after the shift to low temperature and steadily increases for several days. Following activation at 31 °C, cultures continue to make viral DNA for at least 24 hours after they are shifted back to high temperature. Our data suggest that induction of viral multiplication involves the asynchronous occurrence of a unique event, after which DNA synthesis can continue even under non-permissive conditions. Superhelical closed circular dimers and trimers of polyoma DNA are synthesized as well as monomeric molecules. These oligomers amount to 40% of the total viral DNA; they are not obligatory precursors of the monomeric form, which is the only type found in mature virions. Oligomers are not observed (1% or less) after infection of 3T3 cells with either wild type or the Ts-a mutant of polyoma. Several possible models to explain the origin of oligomers, the state of viral DNA in transformed cells and the nature of the activating event are discussed." @default.
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• W1488397830 date "1970-02-01" @default.
• W1488397830 modified "2023-09-24" @default.
• W1488397830 title "Induction of virus multiplication in 3T3 cells transformed by a thermosensitive mutant of polyoma virus" @default.
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• W1488397830 doi "https://doi.org/10.1016/0022-2836(70)90305-0" @default.
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