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• W1488402792 abstract "Publisher Summary This chapter discusses the role of bile acids in the modulation of apoptosis. Bile acids are inherently toxic molecules, which can have a profound influence on cellular function and structure. The proposed mechanisms of bile acid-induced hepatocyte damage range from a simple detergent effect on binding to plasma membranes to the induction of cell death. Bile acids induce apoptosis via ligand-independent, death receptor pathways, involving the Fas receptor and also through classic mitochondrial pathways. In contrast, the oral administration of ursodeoxycholic acid (UDCA) and tauroursodeoxycholic acid (TUDCA) has been used clinically for years to treat cholestasis and a number of other liver diseases. There is now strong evidence that the cytoprotective mechanism of UDCA and its conjugates results from their ability to inhibit apoptosis in hepatic cells. Interestingly, the anti-apoptotic properties of these bile acids are independent of the cell type and death signal, suggesting a common anti-apoptotic mechanism(s). Specifically, UDCA prevents apoptosis by modulating mitochondrial membrane perturbation, opening of the permeability transition pore, Bax translocation, cytochrome c release, and subsequent caspase activation and substrate cleavage. Apoptosis can not only be inhibited by blocking pro-apoptotic pathways but also by activating survival signals for example through the cAMP, Akt, NF-κB, MAPK and PI3K-mediated pathways." @default.
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• W1488402792 date "2004-01-01" @default.
• W1488402792 modified "2023-09-26" @default.
• W1488402792 title "5. THE ROLE OF BILE ACIDS IN THE MODULATION OF APOPTOSIS" @default.
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• W1488402792 doi "https://doi.org/10.1016/s1569-2582(04)15005-8" @default.
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