FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1488537054> ?p ?o ?g. }

• W1488537054 endingPage "487" @default.
• W1488537054 startingPage "480" @default.
• W1488537054 abstract "Astrocytes harbour functional receptors to many neurotransmitters, including substance P (SP), an undecapeptide belonging to the tachykinin family of peptide transmitters. SP activates malignant glial cells to induce cytokine release and proliferation, both responses being relevant for tumour progression. In tumours developed in nude mice transplanted subcutaneously (s.c.) to U373 MG human glioma cells, the presence of SP was observed at immunohistochemistry. Although the administration of exogenous SP did not significantly affect the size or development of U373 MG xenograft, a role of SP in supporting glioma progression in vivo was highlighted by the tumour growth inhibition induced by highly specific and selective human tachykinin NK1receptor antagonists (MEN 11467 and MEN 11149). The anti-tumour activity of MEN 11467 was observed both with s.c. or intravenous treatments and was partially reverted by the concomitant administration of exogenous SP. Doxorubicin did not show any activity in controlling U373 MG growth in this in vivo model. A novel therapeutic approach to treat malignant gliomas with tachykinin NK1receptor antagonists is suggested by these findings. © 2000 Cancer Research Campaign" @default.
• W1488537054 created "2016-06-24" @default.
• W1488537054 creator A5042601047 @default.
• W1488537054 creator A5059955356 @default.
• W1488537054 creator A5076710001 @default.
• W1488537054 creator A5089436979 @default.
• W1488537054 creator A5091013748 @default.
• W1488537054 creator A5030116404 @default.
• W1488537054 date "2000-01-01" @default.
• W1488537054 modified "2023-10-14" @default.
• W1488537054 title "Anti-tumour activity of tachykinin NK1 receptor antagonists on human glioma U373 MG xenograft" @default.
• W1488537054 cites W1632492912 @default.
• W1488537054 cites W1860985526 @default.
• W1488537054 cites W1915538262 @default.
• W1488537054 cites W1966949725 @default.
• W1488537054 cites W1974412135 @default.
• W1488537054 cites W1975305767 @default.
• W1488537054 cites W1977786504 @default.
• W1488537054 cites W1991783561 @default.
• W1488537054 cites W2002356709 @default.
• W1488537054 cites W2006276139 @default.
• W1488537054 cites W2016561850 @default.
• W1488537054 cites W2016871236 @default.
• W1488537054 cites W2017926886 @default.
• W1488537054 cites W2020835847 @default.
• W1488537054 cites W2051564443 @default.
• W1488537054 cites W2053889778 @default.
• W1488537054 cites W2074575591 @default.
• W1488537054 cites W2078418435 @default.
• W1488537054 cites W2080386965 @default.
• W1488537054 cites W2080430730 @default.
• W1488537054 cites W2083653976 @default.
• W1488537054 cites W2087017339 @default.
• W1488537054 cites W2102214373 @default.
• W1488537054 cites W2113579215 @default.
• W1488537054 cites W2140213752 @default.
• W1488537054 cites W2141942162 @default.
• W1488537054 cites W2146390263 @default.
• W1488537054 doi "https://doi.org/10.1054/bjoc.1999.0946" @default.
• W1488537054 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2363296" @default.
• W1488537054 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10646908" @default.
• W1488537054 hasPublicationYear "2000" @default.
• W1488537054 type Work @default.
• W1488537054 sameAs 1488537054 @default.
• W1488537054 citedByCount "63" @default.
• W1488537054 countsByYear W14885370542012 @default.
• W1488537054 countsByYear W14885370542013 @default.
• W1488537054 countsByYear W14885370542014 @default.
• W1488537054 countsByYear W14885370542015 @default.
• W1488537054 countsByYear W14885370542016 @default.
• W1488537054 countsByYear W14885370542017 @default.
• W1488537054 countsByYear W14885370542018 @default.
• W1488537054 countsByYear W14885370542019 @default.
• W1488537054 countsByYear W14885370542020 @default.
• W1488537054 countsByYear W14885370542021 @default.
• W1488537054 countsByYear W14885370542022 @default.
• W1488537054 countsByYear W14885370542023 @default.
• W1488537054 crossrefType "journal-article" @default.
• W1488537054 hasAuthorship W1488537054A5030116404 @default.
• W1488537054 hasAuthorship W1488537054A5042601047 @default.
• W1488537054 hasAuthorship W1488537054A5059955356 @default.
• W1488537054 hasAuthorship W1488537054A5076710001 @default.
• W1488537054 hasAuthorship W1488537054A5089436979 @default.
• W1488537054 hasAuthorship W1488537054A5091013748 @default.
• W1488537054 hasBestOaLocation W14885370541 @default.
• W1488537054 hasConcept C118303440 @default.
• W1488537054 hasConcept C126322002 @default.
• W1488537054 hasConcept C150903083 @default.
• W1488537054 hasConcept C170493617 @default.
• W1488537054 hasConcept C207001950 @default.
• W1488537054 hasConcept C2776533618 @default.
• W1488537054 hasConcept C2776694085 @default.
• W1488537054 hasConcept C2778227246 @default.
• W1488537054 hasConcept C2781303535 @default.
• W1488537054 hasConcept C502942594 @default.
• W1488537054 hasConcept C55938493 @default.
• W1488537054 hasConcept C71924100 @default.
• W1488537054 hasConcept C86803240 @default.
• W1488537054 hasConcept C98274493 @default.
• W1488537054 hasConceptScore W1488537054C118303440 @default.
• W1488537054 hasConceptScore W1488537054C126322002 @default.
• W1488537054 hasConceptScore W1488537054C150903083 @default.
• W1488537054 hasConceptScore W1488537054C170493617 @default.
• W1488537054 hasConceptScore W1488537054C207001950 @default.
• W1488537054 hasConceptScore W1488537054C2776533618 @default.
• W1488537054 hasConceptScore W1488537054C2776694085 @default.
• W1488537054 hasConceptScore W1488537054C2778227246 @default.
• W1488537054 hasConceptScore W1488537054C2781303535 @default.
• W1488537054 hasConceptScore W1488537054C502942594 @default.
• W1488537054 hasConceptScore W1488537054C55938493 @default.
• W1488537054 hasConceptScore W1488537054C71924100 @default.
• W1488537054 hasConceptScore W1488537054C86803240 @default.
• W1488537054 hasConceptScore W1488537054C98274493 @default.
• W1488537054 hasIssue "2" @default.
• W1488537054 hasLocation W14885370541 @default.
• W1488537054 hasLocation W14885370542 @default.
• W1488537054 hasLocation W14885370543 @default.
• W1488537054 hasLocation W14885370544 @default.

• next