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- W148857183 abstract "The development of the nervous system, termed neurogenesis, has been studied in detail on a morphological level in insects, crustaceans and recently also in chelicerates, however, comparable data is missing from myriapods. In addition, nothing is known about the molecules involved in neurogenesis in this group. One reason for this lack of information is that there is no established model system for the study of myriapod development. Thus, before investigating myriapod neurogenesis, I had to decide on a model organism and to establish numerous basic protocols for the intended studies. I chose the millipede Glomeris marginata because adults and eggs are locally available and the embryonic development of this species has been described in detail. After this, I analysed the morphology of the ventral neuroectoderm of G. marginata embryos stained with various markers on whole mounts and serial sections. I found that groups of neural precursors invaginate from the apical surface of the ventral neuroectoderm in a stereotypic pattern, which is comparable to what I observed in a distantly related diplopod, Archispirostreptus sp. Neural precursors arise sequentially in four waves, however, ultimately, all cells of the neurogenic region enter the neural pathway. Thus the mode of neurogenesis found in millipedes is similar to what has been reported for spiders. The major difference is that in G. marginata, cell divisions are associated with the invaginating cell groups, implying that stem cells are present in the ventral neuroectoderm. The molecular part of my research involved the isolation and the analysis of G. marginata homologues of genes that are necessary for neurogenesis in other arthropods. Genes isolated included proneural genes involved in early neurogenesis, neurogenic genes, dorso-ventral patterning genes and markers of later cell fate specification. The expression patterns of these genes was compared to that of homologues in other arthropod species, and, if available, to data from the spider Cupiennius salei. I found that genes are expressed in the expected domains, implying that there is a conserved genetic network controlling the development of the nervous system in arthropods." @default.
- W148857183 created "2016-06-24" @default.
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- W148857183 date "2003-01-01" @default.
- W148857183 modified "2023-09-27" @default.
- W148857183 title "Neurogenesis in the millipede Glomeris marginata (Myriapoda: Diplopoda)" @default.
- W148857183 hasPublicationYear "2003" @default.
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