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- W1488589314 abstract "Five percent of endometrial and ovarian carcinomas are based on a genetic predisposition. Most of the hereditary ovarian cancers (HOC) occur due to deleterious mutations in BRCA1 or BRCA2. Hereditary endometrial cancer (HEC) mainly occurs within the Lynch syndrome or hereditary non-polyposis colon cancer (HNPCC) and is based on mutations in the mismatch repair genes (MLH1, MSH2, MSH6). Besides the positive family history for further endometrial or colon carcinomas in the case of HEC, or further ovarian carcinomas and breast cancer cases in the case of HOC, the clinical feature is the relatively young age of onset, which is under the age of 50 for HEC, and under the age of 55 for HOC. The most effective prevention strategies are prophylactic surgical procedures." @default.
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- W1488589314 date "2008-12-17" @default.
- W1488589314 modified "2023-10-18" @default.
- W1488589314 title "Hereditary Ovarian and Endometrial Cancer" @default.
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- W1488589314 doi "https://doi.org/10.1002/9783527627523.ch12" @default.
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