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- W1488596253 abstract "Studies show that activation of long-terminal-repeat (LTR)-containing retrotransposable gene elements with subsequent insertion into new chromosomal sites could potentially cause genomic instability. This possibility may be examined experimentally by the isolation and functional characterization of “insertase” protein encoded in the 3´ portion of the pol gene of these elements, with subsequent tests for the ability of this insertase protein to cause chromosome breakage in the cell. The experimental approach discusses in this chapter focuses on retroviral LTRs, as they contain both the enhancer–promoter polyadenylation signal sequences for gene transcription and the short inverted-repeat sequences for gene insertion. A chromosomal element carrying two LTRs and adjacent priming sequences would be capable of retrotransposition, if provided with the functions of RNA polymerase, reverse transcriptase, insertase, and other trans-acting factors for transposition. The mouse genome was chosen for the LTR studies described in the chapter as considerable knowledge has been accumulated concerning murine leukemia viruses in relation to leukemogenesis. Research show that it is possible to investigate LTR containing gene elements in the mouse germ line that are related but not expressed in an extracellular virus form." @default.
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- W1488596253 date "1989-01-01" @default.
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- W1488596253 title "Mouse Endogenous Retroviral Long-Terminal-Repeat (LTR) Elements and Environmental Carcinoaenesis" @default.
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- W1488596253 doi "https://doi.org/10.1016/s0079-6603(08)60175-0" @default.
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