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- W1488642777 abstract "ABSTRACT DEFINING A T CELL-INTRINSIC ROLE FOR MYD88 DURING LCMV INFECTION Adeeb Habibur Rahman Laurence Turka, M.D. Immune activation through Toll-like receptors (TLRs) has historically been considered to be a characteristic of cells of the innate, rather than adaptive immune system. Recent studies have challenged this paradigm by demonstrating that TLRs are also expressed on T lymphocytes and that TLR ligands can directly co-stimulate T cell responses in vitro . However, the physiological relevance of these findings during in vivo immune responses was unclear. Mice lacking the critical TLR-adapter protein, myeloid differentiation protein 88 (MyD88), have increased susceptibility to numerous pathogens, highlighting the importance of TLRs in host defense. While the immune impairments associated with MyD88-deficiency have generally been attributed to the importance of MyD88 in regulating innate immune responses, in light of the studies showing that TLRs can directly stimulate T cells, we hypothesized that they may also reflect a direct role for MyD88 in T cells. In this work, we use lymphocytic choriomeningitis virus (LCMV) as a model infection to examine the role of MyD88 in regulating antiviral T cell responses. Using a series of adoptive cell transfer and bone marrow chimera experiments, we identify a critical, but previously unappreciated, T-cell intrinsic role for MyD88 in" @default.
- W1488642777 created "2016-06-24" @default.
- W1488642777 creator A5020454256 @default.
- W1488642777 date "2009-01-01" @default.
- W1488642777 modified "2023-09-23" @default.
- W1488642777 title "Defining a T cell-intrinsic role for MYD88 during LCMV infection" @default.
- W1488642777 cites W1483372876 @default.
- W1488642777 cites W1489480103 @default.
- W1488642777 cites W1489608758 @default.
- W1488642777 cites W1495069464 @default.
- W1488642777 cites W1497721018 @default.
- W1488642777 cites W1514540900 @default.
- W1488642777 cites W1519633296 @default.
- W1488642777 cites W1535492142 @default.
- W1488642777 cites W1591714343 @default.
- W1488642777 cites W1608778557 @default.
- W1488642777 cites W1615242172 @default.
- W1488642777 cites W1627009127 @default.
- W1488642777 cites W1756855871 @default.
- W1488642777 cites W1770811198 @default.
- W1488642777 cites W1793115003 @default.
- W1488642777 cites W1820258609 @default.
- W1488642777 cites W1830583197 @default.
- W1488642777 cites W1832248617 @default.
- W1488642777 cites W1869330944 @default.
- W1488642777 cites W1892684502 @default.
- W1488642777 cites W1905006012 @default.
- W1488642777 cites W1915217100 @default.
- W1488642777 cites W1934712179 @default.
- W1488642777 cites W1950448919 @default.
- W1488642777 cites W1960939533 @default.
- W1488642777 cites W1964077677 @default.
- W1488642777 cites W1966747379 @default.
- W1488642777 cites W1969072247 @default.
- W1488642777 cites W1969430178 @default.
- W1488642777 cites W1969501356 @default.
- W1488642777 cites W1970291282 @default.
- W1488642777 cites W1970910185 @default.
- W1488642777 cites W1971521446 @default.
- W1488642777 cites W1974351164 @default.
- W1488642777 cites W1977939808 @default.
- W1488642777 cites W1980273234 @default.
- W1488642777 cites W1982332591 @default.
- W1488642777 cites W1985834051 @default.
- W1488642777 cites W1986097339 @default.
- W1488642777 cites W1987520669 @default.
- W1488642777 cites W1991236592 @default.
- W1488642777 cites W1991464867 @default.
- W1488642777 cites W1991731944 @default.
- W1488642777 cites W1999070120 @default.
- W1488642777 cites W1999220701 @default.
- W1488642777 cites W1999324987 @default.
- W1488642777 cites W2001740313 @default.
- W1488642777 cites W2001809367 @default.
- W1488642777 cites W2001988677 @default.
- W1488642777 cites W2002061924 @default.
- W1488642777 cites W2003169913 @default.
- W1488642777 cites W2003807404 @default.
- W1488642777 cites W2005570998 @default.
- W1488642777 cites W2006614062 @default.
- W1488642777 cites W2009392385 @default.
- W1488642777 cites W2011427527 @default.
- W1488642777 cites W2011678998 @default.
- W1488642777 cites W2013219140 @default.
- W1488642777 cites W2013472315 @default.
- W1488642777 cites W2014133727 @default.
- W1488642777 cites W2016862474 @default.
- W1488642777 cites W2017120500 @default.
- W1488642777 cites W2017883909 @default.
- W1488642777 cites W202025847 @default.
- W1488642777 cites W2021362028 @default.
- W1488642777 cites W2025412364 @default.
- W1488642777 cites W2029771300 @default.
- W1488642777 cites W2030689421 @default.
- W1488642777 cites W2032917789 @default.
- W1488642777 cites W2033415145 @default.
- W1488642777 cites W2034268908 @default.
- W1488642777 cites W2036528355 @default.
- W1488642777 cites W2040211909 @default.
- W1488642777 cites W2041061869 @default.
- W1488642777 cites W2043801813 @default.
- W1488642777 cites W2047376205 @default.
- W1488642777 cites W2048412291 @default.
- W1488642777 cites W2049449911 @default.
- W1488642777 cites W2051887848 @default.
- W1488642777 cites W2055882175 @default.
- W1488642777 cites W2055942106 @default.
- W1488642777 cites W2057121293 @default.
- W1488642777 cites W2061591986 @default.
- W1488642777 cites W2065050785 @default.
- W1488642777 cites W2067359484 @default.
- W1488642777 cites W2068012172 @default.
- W1488642777 cites W2070597700 @default.
- W1488642777 cites W2071275789 @default.
- W1488642777 cites W2073204639 @default.
- W1488642777 cites W2073906172 @default.
- W1488642777 cites W2074075011 @default.
- W1488642777 cites W2075234503 @default.
- W1488642777 cites W2076361525 @default.
- W1488642777 cites W2079752861 @default.