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- W1488654557 abstract "The phenanthrene-derivative 9-phenanthrol is a recently identified inhibitor of the transient receptor potential melastatin (TRPM) 4 channel, a Ca2+-activated non-selective cation channel whose mechanism of action remains to be determined. Subsequent studies performed on other ion channels confirm the specificity of the drug for TRPM4. In addition, 9-phenanthrol modulates a variety of physiological processes through TRPM4 current inhibition and thus exerts beneficial effects in several pathological conditions. 9-Phenanthrol modulates smooth muscle contraction in bladder and cerebral arteries, affects spontaneous activity in neurons and in the heart, and reduces lipopolysaccharide-induced cell death. Among promising potential applications, 9-phenanthrol exerts cardioprotective effects against ischaemia-reperfusion injuries and reduces ischaemic stroke injuries. In addition to reviewing the biophysical effects of 9-phenanthrol, here we present information about its appropriate use in physiological studies and possible clinical applications." @default.
- W1488654557 created "2016-06-24" @default.
- W1488654557 creator A5023522150 @default.
- W1488654557 creator A5041627885 @default.
- W1488654557 creator A5085138205 @default.
- W1488654557 date "2014-03-18" @default.
- W1488654557 modified "2023-10-01" @default.
- W1488654557 title "The TRPM4 channel inhibitor 9-phenanthrol" @default.
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- W1488654557 doi "https://doi.org/10.1111/bph.12582" @default.
- W1488654557 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3966741" @default.
- W1488654557 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24433510" @default.
- W1488654557 hasPublicationYear "2014" @default.
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