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• W1488683670 abstract "Abstract We investigated the effects of a non‐specific sodium channel blocker (lidocaine) on heat pain thresholds and mechanical impact pain at day 7 and 21 after intradermal injection of 1 μg NGF . Measurements were performed in 12 healthy male subjects prior to and 5 min after intradermal injection of 150 μl lidocaine administered at concentrations of 0.01% (∼0.4 mM) and 0.1% (∼4 mM) to both NGF and control skin sites. NGF caused a maximum reduction of heat pain thresholds at day 7 ( NGF 42.6 ± 0.6 vs. 49.4 ± 0.3 °C in control skin). Lidocaine sensitized normal skin for heat pain, but reduced heat hyperalgesia after NGF at day 7 (44.3 ± 0.8 °C, lidocaine 0.1%; p < 0.005). Pain upon supra‐threshold mechanical impact stimulation was increased after NGF at day 7 ( VAS 29 + 5) and massively enhanced at day 21 ( VAS 64 + 5, p < 0.001). Lidocaine dose‐dependently attenuated mechanically‐induced pain at both control and NGF ‐treated sites. Maximum lidocaine effects on mechanical hyperalgesia were recorded at day 21 in NGF skin (pain reduction to VAS 37 ± 4, p < 0.00001). Repetitive impact stimuli caused increasingly more pain at the NGF sites at day 21 and this pain increase was efficiently suppressed by lidocaine 0.1%. Lidocaine differentially affects NGF ‐induced mechanical hyperalgesia (analgesic effect) and heat sensitivity of nociceptors (sensitizing effect). These opposing responses may be attributed to block of sodium channels vs. sensitization of TRPV1 . NGF ‐evoked extreme mechanical impact pain indicates high action potential discharge frequencies, which might be more susceptible to lidocaine block." @default.
• W1488683670 created "2016-06-24" @default.
• W1488683670 creator A5042907359 @default.
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• W1488683670 date "2012-03-06" @default.
• W1488683670 modified "2023-10-17" @default.
• W1488683670 title "Differential effects of lidocaine on nerve growth factor ( <scp>NGF</scp> )‐evoked heat‐ and mechanical hyperalgesia in humans" @default.
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• W1488683670 doi "https://doi.org/10.1016/j.ejpain.2011.08.004" @default.
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• W1488683670 hasPublicationYear "2012" @default.
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