Matches in SemOpenAlex for { <https://semopenalex.org/work/W1488692391> ?p ?o ?g. }
Showing items 1 to 61 of
61
with 100 items per page.
- W1488692391 endingPage "3798" @default.
- W1488692391 startingPage "3793" @default.
- W1488692391 abstract "New Zealand Black (NZB) mice exhibit polyclonal B cell activation and elevated immunoglobulin production, an abnormality associated with the spontaneous autoimmune disease that affects this strain. To further our understanding of this abnormality of B cell differentiation and maturation, we have employed two-dimensional polyacrylamide gel electrophoresis to analyze the proteins synthesized by lymphocytes of several strains. Two proteins were produced by lymphocytes from NZB mice but not those from normal strains. One was a 16 kd protein with a pI of 5.1, and the other was a 27.5 kd protein with a pI of 4.5. The presence of the xid gene on the NZB background suppressed production of both proteins. They were synthesized by spleen cells but not by bone marrow or lymph node cells, and production was restricted to enlarged B lymphocytes. p16 was synthesized by normal mouse strain B cells upon stimulation with LPS. The 27.5 kd protein was shown to be secreted. On the basis of partial amino acid sequence determination of proteins eluted from gels, p27.5 was identified as J chain and p16 as the C terminal fragment of mu-chain. The synthesis of two other proteins, 13 kd and 18 kd in size, was elevated in NZB spleen lymphocytes. The 18 kd protein was identified as translation initiation factor eIf-4D. The increased level of this protein may be related to the upregulation of immunoglobulin synthesis." @default.
- W1488692391 created "2016-06-24" @default.
- W1488692391 creator A5003463362 @default.
- W1488692391 creator A5015722868 @default.
- W1488692391 creator A5022445392 @default.
- W1488692391 creator A5071953402 @default.
- W1488692391 date "1987-06-01" @default.
- W1488692391 modified "2023-09-23" @default.
- W1488692391 title "Proteins associated with B lymphocyte hyperactivity in New Zealand black mice." @default.
- W1488692391 doi "https://doi.org/10.4049/jimmunol.138.11.3793" @default.
- W1488692391 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3108374" @default.
- W1488692391 hasPublicationYear "1987" @default.
- W1488692391 type Work @default.
- W1488692391 sameAs 1488692391 @default.
- W1488692391 citedByCount "1" @default.
- W1488692391 crossrefType "journal-article" @default.
- W1488692391 hasAuthorship W1488692391A5003463362 @default.
- W1488692391 hasAuthorship W1488692391A5015722868 @default.
- W1488692391 hasAuthorship W1488692391A5022445392 @default.
- W1488692391 hasAuthorship W1488692391A5071953402 @default.
- W1488692391 hasBestOaLocation W14886923911 @default.
- W1488692391 hasConcept C116084860 @default.
- W1488692391 hasConcept C153911025 @default.
- W1488692391 hasConcept C159654299 @default.
- W1488692391 hasConcept C203014093 @default.
- W1488692391 hasConcept C2777761686 @default.
- W1488692391 hasConcept C2778453870 @default.
- W1488692391 hasConcept C2780931953 @default.
- W1488692391 hasConcept C86803240 @default.
- W1488692391 hasConcept C956191 @default.
- W1488692391 hasConceptScore W1488692391C116084860 @default.
- W1488692391 hasConceptScore W1488692391C153911025 @default.
- W1488692391 hasConceptScore W1488692391C159654299 @default.
- W1488692391 hasConceptScore W1488692391C203014093 @default.
- W1488692391 hasConceptScore W1488692391C2777761686 @default.
- W1488692391 hasConceptScore W1488692391C2778453870 @default.
- W1488692391 hasConceptScore W1488692391C2780931953 @default.
- W1488692391 hasConceptScore W1488692391C86803240 @default.
- W1488692391 hasConceptScore W1488692391C956191 @default.
- W1488692391 hasIssue "11" @default.
- W1488692391 hasLocation W14886923911 @default.
- W1488692391 hasLocation W14886923912 @default.
- W1488692391 hasOpenAccess W1488692391 @default.
- W1488692391 hasPrimaryLocation W14886923911 @default.
- W1488692391 hasRelatedWork W1547798144 @default.
- W1488692391 hasRelatedWork W1984372436 @default.
- W1488692391 hasRelatedWork W2027928210 @default.
- W1488692391 hasRelatedWork W2068999859 @default.
- W1488692391 hasRelatedWork W2360587303 @default.
- W1488692391 hasRelatedWork W2375480979 @default.
- W1488692391 hasRelatedWork W2531435013 @default.
- W1488692391 hasRelatedWork W3029908218 @default.
- W1488692391 hasRelatedWork W3031502370 @default.
- W1488692391 hasRelatedWork W8052553 @default.
- W1488692391 hasVolume "138" @default.
- W1488692391 isParatext "false" @default.
- W1488692391 isRetracted "false" @default.
- W1488692391 magId "1488692391" @default.
- W1488692391 workType "article" @default.