Matches in SemOpenAlex for { <https://semopenalex.org/work/W1488695148> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W1488695148 endingPage "23" @default.
- W1488695148 startingPage "1715" @default.
- W1488695148 abstract "The incorporation of I125-labeled 5-iodo-2′-deoxyuridine (IUdR) into the deoxyribonucleic acid (DNA) of several mouse tissues (Adenocarcinoma 755, spleen, small intestine, liver) was measured at intervals up to 6 days after administration of the drug in a saline solution and in a depot form. The incorporation of IUdR into the DNA of human tissues (pancreatic carcinoma, skin, omentum, small intestine, muscle) was also determined after administration of IUdR by intravenous infusion. The drug dosage (50–200 mg/kg/injection in mice, 15 mg/kg in 24 hours in a patient) and regimens of administration were chosen in all experiments to approximate those used in radiosensitization experiments and clinical trials. The levels of IUdR incorporated into the DNA of the neoplasms studied (up to about 1 per cent of thymidine replaced by IUdR) approached those which would be expected to increase the radiation sensitivity of the cells. When measured during the first 24 hours after drug administration, the incorporation of IUdR into the DNA of mouse spleen and small intestine and of human skin and small intestine equaled or exceeded that in the DNA of the tumors. Six days after drug administration, however, IUdR incorporation into the DNA of the mouse tumor equaled or exceeded that into the DNA of the normal tissues. The incorporation of the drug into DNA of all tissues was proportional to the total dose administered, was 2.3–5.5 times greater after the administration of the drug in depot form as compared with administration in saline solution, and was 42–61 per cent higher after pretreatment with the thymidylate synthetase inhibitor, 5-fluoro-2′-deoxyuridine, than when given alone to mice. These results indicate that the mode and schedule of drug administration and the timing of radiotherapy may play an important, even decisive, role in the efficacy of combined therapy with such drugs." @default.
- W1488695148 created "2016-06-24" @default.
- W1488695148 creator A5022389758 @default.
- W1488695148 creator A5044704219 @default.
- W1488695148 creator A5055987554 @default.
- W1488695148 creator A5067483673 @default.
- W1488695148 creator A5077120756 @default.
- W1488695148 creator A5086371803 @default.
- W1488695148 date "1963-12-01" @default.
- W1488695148 modified "2023-09-23" @default.
- W1488695148 title "INCORPORATION OF I-125-LABELED IODODEOXYURIDINE INTO THE DEOXYRIBONUCLEIC ACID OF MURINE AND HUMAN TISSUES FOLLOWING THERAPEUTIC DOSES." @default.
- W1488695148 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14082864" @default.
- W1488695148 hasPublicationYear "1963" @default.
- W1488695148 type Work @default.
- W1488695148 sameAs 1488695148 @default.
- W1488695148 citedByCount "11" @default.
- W1488695148 crossrefType "journal-article" @default.
- W1488695148 hasAuthorship W1488695148A5022389758 @default.
- W1488695148 hasAuthorship W1488695148A5044704219 @default.
- W1488695148 hasAuthorship W1488695148A5055987554 @default.
- W1488695148 hasAuthorship W1488695148A5067483673 @default.
- W1488695148 hasAuthorship W1488695148A5077120756 @default.
- W1488695148 hasAuthorship W1488695148A5086371803 @default.
- W1488695148 hasConcept C142724271 @default.
- W1488695148 hasConcept C153911025 @default.
- W1488695148 hasConcept C185592680 @default.
- W1488695148 hasConcept C203014093 @default.
- W1488695148 hasConcept C2776093070 @default.
- W1488695148 hasConcept C2777108182 @default.
- W1488695148 hasConcept C2777882243 @default.
- W1488695148 hasConcept C2780035454 @default.
- W1488695148 hasConcept C2780931953 @default.
- W1488695148 hasConcept C552990157 @default.
- W1488695148 hasConcept C55493867 @default.
- W1488695148 hasConcept C71924100 @default.
- W1488695148 hasConcept C86803240 @default.
- W1488695148 hasConcept C98274493 @default.
- W1488695148 hasConceptScore W1488695148C142724271 @default.
- W1488695148 hasConceptScore W1488695148C153911025 @default.
- W1488695148 hasConceptScore W1488695148C185592680 @default.
- W1488695148 hasConceptScore W1488695148C203014093 @default.
- W1488695148 hasConceptScore W1488695148C2776093070 @default.
- W1488695148 hasConceptScore W1488695148C2777108182 @default.
- W1488695148 hasConceptScore W1488695148C2777882243 @default.
- W1488695148 hasConceptScore W1488695148C2780035454 @default.
- W1488695148 hasConceptScore W1488695148C2780931953 @default.
- W1488695148 hasConceptScore W1488695148C552990157 @default.
- W1488695148 hasConceptScore W1488695148C55493867 @default.
- W1488695148 hasConceptScore W1488695148C71924100 @default.
- W1488695148 hasConceptScore W1488695148C86803240 @default.
- W1488695148 hasConceptScore W1488695148C98274493 @default.
- W1488695148 hasLocation W14886951481 @default.
- W1488695148 hasOpenAccess W1488695148 @default.
- W1488695148 hasPrimaryLocation W14886951481 @default.
- W1488695148 hasRelatedWork W1990104446 @default.
- W1488695148 hasRelatedWork W2040879809 @default.
- W1488695148 hasRelatedWork W2044147792 @default.
- W1488695148 hasRelatedWork W2050302848 @default.
- W1488695148 hasRelatedWork W2059371216 @default.
- W1488695148 hasRelatedWork W2136674790 @default.
- W1488695148 hasRelatedWork W2413150232 @default.
- W1488695148 hasRelatedWork W2413759787 @default.
- W1488695148 hasRelatedWork W2415892430 @default.
- W1488695148 hasRelatedWork W2905111812 @default.
- W1488695148 hasVolume "23" @default.
- W1488695148 isParatext "false" @default.
- W1488695148 isRetracted "false" @default.
- W1488695148 magId "1488695148" @default.
- W1488695148 workType "article" @default.