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• W1488786650 startingPage "334" @default.
• W1488786650 abstract "Interferon-γ (IFN-γ) is a macrophage-activating cytokine that serves critical functions in innate and adaptive immunity and is thought to be mediated by the Jak-Stat signaling pathway. The present study establishes for the first time that cyclic adenosine monophosphate, protein kinase A, and cAMP response element-binding protein (cAMP/PKA/CREB) are coregulators of the IFN-γ signaling pathway. Experimental data indicate that exogenous IFN-γ stimulated cAMP accumulation and PKA activation in time-dependent and dose-dependent manners in murine peritoneal macrophages. Moreover, IFN-γ stimulated CREB phosphorylation and CREB DNA binding, which could be significantly attenuated by PKA inhibition with H89. It appears that a novel cAMP/PKA/CREB signaling pathway is activated by IFN-γ in macrophages, suggesting that an alternate signaling pathway exists in macrophages in response to IFN-γ." @default.
• W1488786650 created "2016-06-24" @default.
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• W1488786650 date "2004-06-01" @default.
• W1488786650 modified "2023-10-09" @default.
• W1488786650 title "IFN-<i>γ</i>Activates cAMP/PKA/CREB Signaling Pathway in Murine Peritoneal Macrophages" @default.
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• W1488786650 doi "https://doi.org/10.1089/107999004323142196" @default.
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