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• W1488793082 startingPage "492" @default.
• W1488793082 abstract "Formation of the CO compound has been studied in intact mitochondria, submitochondrial particles and isolated cytochrome oxidase. The reaction requires the prior reduction of both cytochrome a3 and one other single-electron acceptor. It is inferred that the second acceptor is the “invisible” copper which is undetectable by both optical and spin resonance spectroscopy. The overall process can be viewed as two single electron steps plus a ligand binding reaction. At high concentrations of CO, when titrations are performed at oxidation-reduction potentials significantly above the midpoints of either cytochrome a3 or “invisible” copper, appearance of the CO compound follows a strict n = 2 (2-electron) relationship. Its midpoint potential is also dependent on the prevailing concentration of CO and is increased by approx. 30 mV for each tenfold increase in the level of CO. At redox potentials approaching the midpoints of cytochrome a3 or “invisible” copper, significant deviations from n = 2 behavior are apparent which are readily detectable experimentally using low CO concentrations. A mathematical analysis of this model is presented and the oxidation-reduction properties of the CO compound are utilized to determine the midpoint potential of the “invisible” copper. This value is estimated to be 340 ± 10 mV at pH 7.8, independent of pH and the prevailing sol[ATP][ADP] × [P1] ratio. By analogy with the observations on CO binding, the primary intermediate in the oxidase reaction with oxygen is concluded to be a bridged a32+-O2-Cu1+ complex. The initial reduction of molecular oxygen can then proceed via a thermodynamically favorable two-electron step to form a bridged peroxide intermediate. Subsequent reduction to water may later occur by way of two single-electron steps or one two-electron step." @default.
• W1488793082 created "2016-06-24" @default.
• W1488793082 creator A5001074686 @default.
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• W1488793082 date "1975-08-01" @default.
• W1488793082 modified "2023-09-25" @default.
• W1488793082 title "The invisible copper of cytochrome c oxidase" @default.
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• W1488793082 doi "https://doi.org/10.1016/0003-9861(75)90192-7" @default.
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• W1488793082 hasPublicationYear "1975" @default.
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