FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1488895437> ?p ?o ?g. }

• W1488895437 endingPage "22" @default.
• W1488895437 startingPage "10" @default.
• W1488895437 abstract "Ascidiacyclamide (ASC), cyclo(-Ile1-Oxz2-d-Val3-Thz4-)2 (Oxz=oxazoline and Thz=thiazole) has a C2-symmetric sequence, and the relationships between its conformation and symmetry have been studied. In a previous study, we performed asymmetric modifications in which an Ile residue was replaced by Gly, Leu or Phe to disturb the symmetry [Doi et al. (1999) Biopolymers49, 459-469]. In this study, the modifications were extended. The Ile1 residue was replaced by Gly, Ala, aminoisobutyric acid (Aib), Val, Leu, Phe or d-Ile, and the d-Val3 residue was replaced by Val. The structures of these analogs were analyzed by X-ray diffraction, 1H NMR and CD techniques. X-Ray diffraction analyses revealed that the [Ala1], [Aib1] and [Phe1]ASC analogs are folded, whereas [Val1]ASC has a square form. These structures are the first examples of folded structures for ASC analogs in the crystal state and are similar to the previously reported structures of [Gly1] and [Phe1]ASC in solution. The resonances of amide NH and Thz CH protons linearly shift with temperature changes; in particular, those of [Aib1], [d-Ile1] and [Val3]ASCs exhibited a large temperature dependence. DMSO titration caused nonlinear shifts of proton resonances for all analogs and largely affected [d-Ile1] and [Val3]ASCs. A similar tendency was observed upon the addition of acetone to peptide solutions. Regarding peptide concentration changes, amide NH and Thz CH protons of [Gly1]ASC showed a relatively large dependence. CD spectra of these analogs indicated approximately two patterns in MeCN solution, which were related to the crystal structures. However, all spectra showed a similar positive Cotton effect in TFE solution, except that of [Val3]ASC. In the cytotoxicity test using P388 cells, [Val1]ASC exhibited the strongest activity, whereas the epimers of ASC ([d-Ile1] and [Val3]ASCs), showed fairly moderate activities." @default.
• W1488895437 created "2016-06-24" @default.
• W1488895437 creator A5001466041 @default.
• W1488895437 creator A5019037478 @default.
• W1488895437 creator A5020621427 @default.
• W1488895437 creator A5025106836 @default.
• W1488895437 creator A5038826847 @default.
• W1488895437 creator A5047822588 @default.
• W1488895437 creator A5060611371 @default.
• W1488895437 creator A5062364842 @default.
• W1488895437 creator A5064971574 @default.
• W1488895437 creator A5078404817 @default.
• W1488895437 creator A5081458796 @default.
• W1488895437 creator A5088889186 @default.
• W1488895437 creator A5089590850 @default.
• W1488895437 date "2008-12-05" @default.
• W1488895437 modified "2023-10-06" @default.
• W1488895437 title "Effect of asymmetric modification on the conformation of ascidiacyclamide analogs" @default.
• W1488895437 cites W1535899734 @default.
• W1488895437 cites W1582415996 @default.
• W1488895437 cites W1967238637 @default.
• W1488895437 cites W1982701825 @default.
• W1488895437 cites W1985739753 @default.
• W1488895437 cites W1989469518 @default.
• W1488895437 cites W1999485045 @default.
• W1488895437 cites W2008171066 @default.
• W1488895437 cites W2024600508 @default.
• W1488895437 cites W2026940054 @default.
• W1488895437 cites W2027741614 @default.
• W1488895437 cites W2028980145 @default.
• W1488895437 cites W2036724067 @default.
• W1488895437 cites W2041257828 @default.
• W1488895437 cites W2041385906 @default.
• W1488895437 cites W2044105679 @default.
• W1488895437 cites W2046251906 @default.
• W1488895437 cites W2055943898 @default.
• W1488895437 cites W2060781833 @default.
• W1488895437 cites W2073136611 @default.
• W1488895437 cites W2084779147 @default.
• W1488895437 cites W2116880901 @default.
• W1488895437 cites W2151280091 @default.
• W1488895437 cites W2156330822 @default.
• W1488895437 cites W2161575522 @default.
• W1488895437 cites W2952989434 @default.
• W1488895437 cites W2953341171 @default.
• W1488895437 cites W3004852473 @default.
• W1488895437 cites W55890731 @default.
• W1488895437 doi "https://doi.org/10.1034/j.1399-3011.2002.02981.x" @default.
• W1488895437 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12081623" @default.
• W1488895437 hasPublicationYear "2008" @default.
• W1488895437 type Work @default.
• W1488895437 sameAs 1488895437 @default.
• W1488895437 citedByCount "22" @default.
• W1488895437 countsByYear W14888954372012 @default.
• W1488895437 countsByYear W14888954372013 @default.
• W1488895437 countsByYear W14888954372014 @default.
• W1488895437 countsByYear W14888954372015 @default.
• W1488895437 countsByYear W14888954372016 @default.
• W1488895437 countsByYear W14888954372017 @default.
• W1488895437 countsByYear W14888954372018 @default.
• W1488895437 countsByYear W14888954372019 @default.
• W1488895437 countsByYear W14888954372020 @default.
• W1488895437 countsByYear W14888954372021 @default.
• W1488895437 countsByYear W14888954372023 @default.
• W1488895437 crossrefType "journal-article" @default.
• W1488895437 hasAuthorship W1488895437A5001466041 @default.
• W1488895437 hasAuthorship W1488895437A5019037478 @default.
• W1488895437 hasAuthorship W1488895437A5020621427 @default.
• W1488895437 hasAuthorship W1488895437A5025106836 @default.
• W1488895437 hasAuthorship W1488895437A5038826847 @default.
• W1488895437 hasAuthorship W1488895437A5047822588 @default.
• W1488895437 hasAuthorship W1488895437A5060611371 @default.
• W1488895437 hasAuthorship W1488895437A5062364842 @default.
• W1488895437 hasAuthorship W1488895437A5064971574 @default.
• W1488895437 hasAuthorship W1488895437A5078404817 @default.
• W1488895437 hasAuthorship W1488895437A5081458796 @default.
• W1488895437 hasAuthorship W1488895437A5088889186 @default.
• W1488895437 hasAuthorship W1488895437A5089590850 @default.
• W1488895437 hasConcept C103319777 @default.
• W1488895437 hasConcept C115624301 @default.
• W1488895437 hasConcept C178790620 @default.
• W1488895437 hasConcept C185592680 @default.
• W1488895437 hasConcept C2778439535 @default.
• W1488895437 hasConcept C2779281246 @default.
• W1488895437 hasConcept C2781338088 @default.
• W1488895437 hasConcept C55493867 @default.
• W1488895437 hasConcept C71240020 @default.
• W1488895437 hasConcept C8010536 @default.
• W1488895437 hasConceptScore W1488895437C103319777 @default.
• W1488895437 hasConceptScore W1488895437C115624301 @default.
• W1488895437 hasConceptScore W1488895437C178790620 @default.
• W1488895437 hasConceptScore W1488895437C185592680 @default.
• W1488895437 hasConceptScore W1488895437C2778439535 @default.
• W1488895437 hasConceptScore W1488895437C2779281246 @default.
• W1488895437 hasConceptScore W1488895437C2781338088 @default.
• W1488895437 hasConceptScore W1488895437C55493867 @default.
• W1488895437 hasConceptScore W1488895437C71240020 @default.
• W1488895437 hasConceptScore W1488895437C8010536 @default.

• next