FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1488915914> ?p ?o ?g. }

• W1488915914 endingPage "60" @default.
• W1488915914 startingPage "253" @default.
• W1488915914 abstract "To investigate nevirapine concentrations in African HIV-infected children receiving divided Triomune tablets (stavudine+lamivudine+nevirapine).Cross-sectional study.Steady-state plasma nevirapine concentrations were determined in Malawian and Zambian children aged 8 months to 18 years receiving Triomune in routine outpatient settings. Predictors from height-for-age, body mass index (BMI)-for-age, age, sex, post-dose sampling time and dose/m2/day were investigated using centre-stratified regression with backwards elimination (P<0.1).Of the 71 Malawian and 56 Zambian children (median age 8.4 vs 8.5 years, height-for-age -3.15 vs -1.84, respectively), only 1 (3%) of those prescribed > or =300 mg/m2/day nevirapine had subtherapeutic concentrations (<3 mg/l) compared with 22 (23%) of those prescribed <300 mg/m2/day; most children with subtherapeutic nevirapine concentrations were taking half or quarter Triomune tablets. Lower nevirapine concentrations were independently associated with lower height-for-age (indicating stunting) (0.37 mg/l per unit higher [95% confidence interval (CI): -0.003, +0.74]; P=0.05), lower prescribed dose/m2 (+0.89 mg/l per 50 mg/m2 higher [95% CI: 0.32, 1.46]; P=0.002) and higher BMI-for-age (indicating lack of wasting) (-0.42 mg/l per unit higher [95% CI: -0.80, -0.04]; P=0.03).Currently available adult fixed-dose combination tablets are not well suited to children, particularly at younger ages: Triomune 30 is preferable to Triomune 40 because of the higher dose of nevirapine relative to stavudine. Further research is required to confirm that concentrations are reduced in stunted children but increased in wasted children. Development of appropriate paediatric fixed-dose combination tablets is essential if antiretroviral therapy is to be made widely available to children in resource-limited settings." @default.
• W1488915914 created "2016-06-24" @default.
• W1488915914 creator A5001331694 @default.
• W1488915914 creator A5012522909 @default.
• W1488915914 creator A5019646716 @default.
• W1488915914 creator A5021568119 @default.
• W1488915914 creator A5039454974 @default.
• W1488915914 creator A5043723375 @default.
• W1488915914 creator A5044084862 @default.
• W1488915914 creator A5062973431 @default.
• W1488915914 creator A5069205320 @default.
• W1488915914 creator A5069491495 @default.
• W1488915914 creator A5069643896 @default.
• W1488915914 creator A5073473981 @default.
• W1488915914 creator A5087960555 @default.
• W1488915914 date "2007-01-01" @default.
• W1488915914 modified "2023-09-27" @default.
• W1488915914 title "Nevirapine concentrations in HIV-infected children treated with divided fixed-dose combination antiretroviral tablets in Malawi and Zambia." @default.
• W1488915914 cites W1581407744 @default.
• W1488915914 cites W1589735794 @default.
• W1488915914 cites W1981476848 @default.
• W1488915914 cites W1981712752 @default.
• W1488915914 cites W1993641427 @default.
• W1488915914 cites W2002824521 @default.
• W1488915914 cites W2005617325 @default.
• W1488915914 cites W2015185599 @default.
• W1488915914 cites W2038535763 @default.
• W1488915914 cites W2054071802 @default.
• W1488915914 cites W2061577259 @default.
• W1488915914 cites W2065855820 @default.
• W1488915914 cites W2095442537 @default.
• W1488915914 cites W2097946939 @default.
• W1488915914 cites W2124543441 @default.
• W1488915914 cites W2135892517 @default.
• W1488915914 cites W2144905510 @default.
• W1488915914 cites W3023623894 @default.
• W1488915914 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17503667" @default.
• W1488915914 hasPublicationYear "2007" @default.
• W1488915914 type Work @default.
• W1488915914 sameAs 1488915914 @default.
• W1488915914 citedByCount "17" @default.
• W1488915914 countsByYear W14889159142013 @default.
• W1488915914 countsByYear W14889159142014 @default.
• W1488915914 countsByYear W14889159142017 @default.
• W1488915914 countsByYear W14889159142018 @default.
• W1488915914 countsByYear W14889159142021 @default.
• W1488915914 crossrefType "journal-article" @default.
• W1488915914 hasAuthorship W1488915914A5001331694 @default.
• W1488915914 hasAuthorship W1488915914A5012522909 @default.
• W1488915914 hasAuthorship W1488915914A5019646716 @default.
• W1488915914 hasAuthorship W1488915914A5021568119 @default.
• W1488915914 hasAuthorship W1488915914A5039454974 @default.
• W1488915914 hasAuthorship W1488915914A5043723375 @default.
• W1488915914 hasAuthorship W1488915914A5044084862 @default.
• W1488915914 hasAuthorship W1488915914A5062973431 @default.
• W1488915914 hasAuthorship W1488915914A5069205320 @default.
• W1488915914 hasAuthorship W1488915914A5069491495 @default.
• W1488915914 hasAuthorship W1488915914A5069643896 @default.
• W1488915914 hasAuthorship W1488915914A5073473981 @default.
• W1488915914 hasAuthorship W1488915914A5087960555 @default.
• W1488915914 hasConcept C126322002 @default.
• W1488915914 hasConcept C142462285 @default.
• W1488915914 hasConcept C203014093 @default.
• W1488915914 hasConcept C2522874641 @default.
• W1488915914 hasConcept C2776623344 @default.
• W1488915914 hasConcept C2777869810 @default.
• W1488915914 hasConcept C2779130552 @default.
• W1488915914 hasConcept C2779764123 @default.
• W1488915914 hasConcept C2779889181 @default.
• W1488915914 hasConcept C2780593183 @default.
• W1488915914 hasConcept C2993143319 @default.
• W1488915914 hasConcept C3013748606 @default.
• W1488915914 hasConcept C44249647 @default.
• W1488915914 hasConcept C71924100 @default.
• W1488915914 hasConcept C90924648 @default.
• W1488915914 hasConceptScore W1488915914C126322002 @default.
• W1488915914 hasConceptScore W1488915914C142462285 @default.
• W1488915914 hasConceptScore W1488915914C203014093 @default.
• W1488915914 hasConceptScore W1488915914C2522874641 @default.
• W1488915914 hasConceptScore W1488915914C2776623344 @default.
• W1488915914 hasConceptScore W1488915914C2777869810 @default.
• W1488915914 hasConceptScore W1488915914C2779130552 @default.
• W1488915914 hasConceptScore W1488915914C2779764123 @default.
• W1488915914 hasConceptScore W1488915914C2779889181 @default.
• W1488915914 hasConceptScore W1488915914C2780593183 @default.
• W1488915914 hasConceptScore W1488915914C2993143319 @default.
• W1488915914 hasConceptScore W1488915914C3013748606 @default.
• W1488915914 hasConceptScore W1488915914C44249647 @default.
• W1488915914 hasConceptScore W1488915914C71924100 @default.
• W1488915914 hasConceptScore W1488915914C90924648 @default.
• W1488915914 hasIssue "2" @default.
• W1488915914 hasLocation W14889159141 @default.
• W1488915914 hasOpenAccess W1488915914 @default.
• W1488915914 hasPrimaryLocation W14889159141 @default.
• W1488915914 hasRelatedWork W1488915914 @default.
• W1488915914 hasRelatedWork W1658234573 @default.
• W1488915914 hasRelatedWork W2013512709 @default.
• W1488915914 hasRelatedWork W2031442055 @default.

• next