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- W1488925574 abstract "A double-blind clinical study was performed to determine whether the release of progesterone from an intrauterine contraceptive device (IUD) had any effect on IUD event rates. A total of 101 women received intrauterine contraceptive devices containing progesterone, resulting in the accumulation of 877 women-months experience; 100 women received IUD's without steroid, resulting in the accumulation of 780 women-months. The only significant difference was a higher incidence of pregnancy in those patients using devices which did not contain progesterone.In an attempt to develop an IUD with a higher continuation rate, a T-shaped design which also released progesterone at a rate of 65 mcg/day was studied in a test which was planned for 1 year. (The IUDs progesterone was completely released in 13 months). 101 women were fitted with the progesterone device and 100 with similar IUDs without progesterone. All were over age 18 and healthy. 68 women with the inert devices and 76 with progesterone devices were nulliparous. A total of 877 woman-months with the medicated and 780 woman-months with the inert devices were recorded. The test was discontinued earlier than planned because 10 pregnancies occurred among inert device wearers and 2 among medicated device users. Expulsion rates and removals for bleeding or pain were the same in both groups. The progesterone did not result in higher continuation rates than the longer-lasting copper-bearing T-shaped IUDs. The need for annual replacement will limit the usefulness of this device." @default.
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- W1488925574 date "1975-03-01" @default.
- W1488925574 modified "2023-09-24" @default.
- W1488925574 title "Clinical study of a progesterone-releasing intrauterine contraceptive device" @default.
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- W1488925574 doi "https://doi.org/10.1016/0002-9378(75)90476-7" @default.
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