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- W1488978880 abstract "Research Article1 May 1990free access The rhp6+ gene of Schizosaccharomyces pombe: a structural and functional homolog of the RAD6 gene from the distantly related yeast Saccharomyces cerevisiae. P. Reynolds P. Reynolds Department of Biophysics, University of Rochester School of Medicine, NY 14642. Search for more papers by this author M.H. Koken M.H. Koken Department of Biophysics, University of Rochester School of Medicine, NY 14642. Search for more papers by this author J.H. Hoeijmakers J.H. Hoeijmakers Department of Biophysics, University of Rochester School of Medicine, NY 14642. Search for more papers by this author S. Prakash S. Prakash Department of Biophysics, University of Rochester School of Medicine, NY 14642. Search for more papers by this author L. Prakash L. Prakash Department of Biophysics, University of Rochester School of Medicine, NY 14642. Search for more papers by this author P. Reynolds P. Reynolds Department of Biophysics, University of Rochester School of Medicine, NY 14642. Search for more papers by this author M.H. Koken M.H. Koken Department of Biophysics, University of Rochester School of Medicine, NY 14642. Search for more papers by this author J.H. Hoeijmakers J.H. Hoeijmakers Department of Biophysics, University of Rochester School of Medicine, NY 14642. Search for more papers by this author S. Prakash S. Prakash Department of Biophysics, University of Rochester School of Medicine, NY 14642. Search for more papers by this author L. Prakash L. Prakash Department of Biophysics, University of Rochester School of Medicine, NY 14642. Search for more papers by this author Author Information P. Reynolds1, M.H. Koken1, J.H. Hoeijmakers1, S. Prakash1 and L. Prakash1 1Department of Biophysics, University of Rochester School of Medicine, NY 14642. The EMBO Journal (1990)9:1423-1430https://doi.org/10.1002/j.1460-2075.1990.tb08258.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info The RAD6 gene of Saccharomyces cerevisiae encodes a ubiquitin conjugating enzyme and is required for DNA repair, DNA-damage-induced mutagenesis and sporulation. Here, we show that RAD6 and the rhp6+ gene from the distantly related yeast Schizosaccharomyces pombe share a high degree of structural and functional homology. The predominantly acidic carboxyl-terminal 21 amino acids present in the RAD6 protein are absent in the rhp6(+)-encoded protein; otherwise, the two proteins are very similar, with 77% identical residues. Like rad6, null mutations of the rhp6+ gene confer a defect in DNA repair, UV mutagenesis and sporulation, and the RAD6 and rhp6+ genes can functionally substitute for one another. These observations suggest that functional interactions between RAD6 (rhp6+) protein and other components of the DNA repair complex have been conserved among eukaryotes. Previous ArticleNext Article Volume 9Issue 51 May 1990In this issue RelatedDetailsLoading ..." @default.
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- W1488978880 title "The rhp6+ gene of Schizosaccharomyces pombe: a structural and functional homolog of the RAD6 gene from the distantly related yeast Saccharomyces cerevisiae." @default.
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