FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1488992242> ?p ?o ?g. }

• W1488992242 endingPage "946" @default.
• W1488992242 startingPage "937" @default.
• W1488992242 abstract "Autocrine and paracrine regulatory mechanisms ensure integrated secretion of islet hormones that respond efficiently to changes in metabolic need. As proinsulin C-peptide exerts various biological effects and binds to cell membranes including insulin-secreting β cells, its physiological role in insulin release was examined.Insulin releasing activity of human and rat C-peptides were studied in the clonal pancreatic cell line, BRIN-BD11, with findings substantiated using isolated islets and in vivo studies employing SWISS TO mice.Acute exposure of clonal β cells to human C-peptide resulted in concentration-dependent inhibitory effects on insulin secretion at 5.6 mM (p < 0.05-p < 0.001) and 16.7 mM (p < 0.01-p < 0.001) glucose. At physiologically relevant intra-islet concentrations (10(-9) -10(-6) M), C-peptide suppressed the insulin-secretory responses to a range of secretagogues acting at different points in the β cell stimulus-secretion coupling pathway including alanine (p < 0.05), Ca(2+) (p < 0.001), arginine (p < 0.05), tolbutamide (p < 0.001), glucagon-like peptide 1 (GLP-1) (p < 0.001), isobutylmethylxanthine (IBMX) (p < 0.01) and KCl (p < 0.05). Similar results were obtained using isolated mouse pancreatic islets. Human C-peptide (3 × 10(-7) M, p < 0.001), somatostatin-14 (3 × 10(-7) M, p < 0.01) and diazoxide (300 µM, p < 0.001) reduced both alanine and glucose-stimulated insulin release by 43, 25 and 48%, respectively. The effects of human C-peptide were reproduced using rat C-peptide I and II. C-peptide also inhibited in vivo glucose-stimulated insulin release and impaired glucose tolerance in mice.C-peptide is a biologically active endogenous peptide hormone that exerts inhibitory autocrine effects on pancreatic β-cell function. Mechanisms involving the activation of K(+) channels and a distal effect downstream of increased cytoplasmic Ca(2+) appear to be implicated in the inhibition of insulin secretion." @default.
• W1488992242 created "2016-06-24" @default.
• W1488992242 creator A5016108962 @default.
• W1488992242 creator A5035600037 @default.
• W1488992242 creator A5042327848 @default.
• W1488992242 creator A5075620817 @default.
• W1488992242 date "2014-04-27" @default.
• W1488992242 modified "2023-10-05" @default.
• W1488992242 title "Evidence for inhibitory autocrine effects of proinsulin C-peptide on pancreatic<i>β</i>-cell function and insulin secretion" @default.
• W1488992242 cites W1497413827 @default.
• W1488992242 cites W1569610117 @default.
• W1488992242 cites W1971927678 @default.
• W1488992242 cites W1979183493 @default.
• W1488992242 cites W1984170856 @default.
• W1488992242 cites W1988621352 @default.
• W1488992242 cites W1990827407 @default.
• W1488992242 cites W1993239989 @default.
• W1488992242 cites W1997301909 @default.
• W1488992242 cites W1998596237 @default.
• W1488992242 cites W1999141938 @default.
• W1488992242 cites W2008003270 @default.
• W1488992242 cites W2010671738 @default.
• W1488992242 cites W2018837760 @default.
• W1488992242 cites W2019531067 @default.
• W1488992242 cites W2019926410 @default.
• W1488992242 cites W2020051830 @default.
• W1488992242 cites W2028431435 @default.
• W1488992242 cites W2030670787 @default.
• W1488992242 cites W2041648277 @default.
• W1488992242 cites W2041677175 @default.
• W1488992242 cites W2049583719 @default.
• W1488992242 cites W2049724153 @default.
• W1488992242 cites W2064457050 @default.
• W1488992242 cites W2082040090 @default.
• W1488992242 cites W2083349986 @default.
• W1488992242 cites W2086048942 @default.
• W1488992242 cites W2094771121 @default.
• W1488992242 cites W2095556628 @default.
• W1488992242 cites W2095923443 @default.
• W1488992242 cites W2096229739 @default.
• W1488992242 cites W2102515007 @default.
• W1488992242 cites W2130623416 @default.
• W1488992242 cites W2134138856 @default.
• W1488992242 cites W2138065933 @default.
• W1488992242 cites W2143255381 @default.
• W1488992242 cites W2143914125 @default.
• W1488992242 cites W2161924429 @default.
• W1488992242 cites W2163269399 @default.
• W1488992242 cites W2324038097 @default.
• W1488992242 cites W2460183954 @default.
• W1488992242 cites W4232587045 @default.
• W1488992242 doi "https://doi.org/10.1111/dom.12300" @default.
• W1488992242 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24702738" @default.
• W1488992242 hasPublicationYear "2014" @default.
• W1488992242 type Work @default.
• W1488992242 sameAs 1488992242 @default.
• W1488992242 citedByCount "15" @default.
• W1488992242 countsByYear W14889922422014 @default.
• W1488992242 countsByYear W14889922422015 @default.
• W1488992242 countsByYear W14889922422017 @default.
• W1488992242 countsByYear W14889922422018 @default.
• W1488992242 countsByYear W14889922422019 @default.
• W1488992242 countsByYear W14889922422020 @default.
• W1488992242 countsByYear W14889922422021 @default.
• W1488992242 countsByYear W14889922422022 @default.
• W1488992242 crossrefType "journal-article" @default.
• W1488992242 hasAuthorship W1488992242A5016108962 @default.
• W1488992242 hasAuthorship W1488992242A5035600037 @default.
• W1488992242 hasAuthorship W1488992242A5042327848 @default.
• W1488992242 hasAuthorship W1488992242A5075620817 @default.
• W1488992242 hasConcept C126322002 @default.
• W1488992242 hasConcept C134018914 @default.
• W1488992242 hasConcept C165220095 @default.
• W1488992242 hasConcept C170493617 @default.
• W1488992242 hasConcept C185592680 @default.
• W1488992242 hasConcept C2776297358 @default.
• W1488992242 hasConcept C2779306644 @default.
• W1488992242 hasConcept C71924100 @default.
• W1488992242 hasConcept C7876069 @default.
• W1488992242 hasConcept C86803240 @default.
• W1488992242 hasConcept C90061646 @default.
• W1488992242 hasConceptScore W1488992242C126322002 @default.
• W1488992242 hasConceptScore W1488992242C134018914 @default.
• W1488992242 hasConceptScore W1488992242C165220095 @default.
• W1488992242 hasConceptScore W1488992242C170493617 @default.
• W1488992242 hasConceptScore W1488992242C185592680 @default.
• W1488992242 hasConceptScore W1488992242C2776297358 @default.
• W1488992242 hasConceptScore W1488992242C2779306644 @default.
• W1488992242 hasConceptScore W1488992242C71924100 @default.
• W1488992242 hasConceptScore W1488992242C7876069 @default.
• W1488992242 hasConceptScore W1488992242C86803240 @default.
• W1488992242 hasConceptScore W1488992242C90061646 @default.
• W1488992242 hasIssue "10" @default.
• W1488992242 hasLocation W14889922421 @default.
• W1488992242 hasLocation W14889922422 @default.
• W1488992242 hasOpenAccess W1488992242 @default.
• W1488992242 hasPrimaryLocation W14889922421 @default.
• W1488992242 hasRelatedWork W1979462991 @default.

• next