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- W1489062194 abstract "Summary The administration of a saturating dose of either India ink or Thorotrast prior to or within 24 hours after the intraportal injection of Walker 256 carcinoma cells resulted in an increased incidence and size of artificially induced hepatic metastases. The enhancing effect of reticuloendothelial interference on tumor “takes” may be explained as being due to a trapping of injected tumor cells as a result of marked swelling of Kupffer cells with sinusoidal occlusion and hepatic parenchymal damage which was observed after the administration of both Thorotrast and India ink. These mechanisms abrogate the necessity of relating such an effect to an inhibitory action of these agents on a specific activity of the reticuloendothelial system associated with tumor resistance. Established hepatic metastases of Walker 256 carcinoma fail to influence the phagocytic activity of the reticuloendothelial system as disclosed by a normal blood clearance of carbon particles. Similarly carbon clearance was normal when observed in animals 14 days after tumor cell injection but in whom hepatic metastases were not demonstrable." @default.
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- W1489062194 date "1961-02-01" @default.
- W1489062194 modified "2023-09-23" @default.
- W1489062194 title "Experimental studies of factors influencing hepatic metastases. VII. Effect of reticuloendothelial interference." @default.
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