FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1489065599> ?p ?o ?g. }

• W1489065599 endingPage "4255" @default.
• W1489065599 startingPage "4255" @default.
• W1489065599 abstract "To investigate whether Epigallocatechin-3-gallate (EGCG) can induce apoptosis of the gastric cancer cell line MKN45 and its apoptotic pathway.To determine this, apoptotic rates of MKN45 cells after EGCG treatment with or without caspase-3 inhibitor were evaluated by Annexin V-FITC + PI staining The influence of EGCG on the activity of caspase-3 in the MKN45 cells was determined by ELISA. By Rhodamine123 staining, the membrane potential change of the mitochondrion was also investigated, and mRNAs and protein expression of the bcl-2 family were analyzed by RT-PCR and Western blot.EGCG can induce apoptosis of MKN45 cells in time- and dose-dependent manner. Eight hours after EGCG treatment, the activity of caspase-3 in the MKN45 increased, especially 12 h after treatment. The mitochondrial membrane potential was significantly weakened 4 h after EGCG insult. The mRNA and protein expression levels of pro-apoptotic members, such as Bax, Bid and Bad, were upregulated gradually as treated time increased. Moreover, the mRNA and protein expression levels of anti-apoptotic members, such as Bcl-xL and Bcl-2, were inhibited.These data support that EGCG can induce apoptosis of the human gastric cancer cell line MKN45, and the effect is in a time- and dose-dependent manner. The apoptotic pathway triggered by EGCG in MKN45 is mitochondrial-dependent." @default.
• W1489065599 created "2016-06-24" @default.
• W1489065599 creator A5016496299 @default.
• W1489065599 creator A5043275598 @default.
• W1489065599 creator A5081075504 @default.
• W1489065599 creator A5091758507 @default.
• W1489065599 date "2007-01-01" @default.
• W1489065599 modified "2023-10-17" @default.
• W1489065599 title "Apoptotic effect of Epigallocatechin-3-gallate on the human gastric cancer cell line MKN45<i>via</i>activation of the mitochondrial pathway" @default.
• W1489065599 cites W1607777232 @default.
• W1489065599 cites W1644516630 @default.
• W1489065599 cites W1819691041 @default.
• W1489065599 cites W1913701520 @default.
• W1489065599 cites W1962476452 @default.
• W1489065599 cites W1967108608 @default.
• W1489065599 cites W1970530418 @default.
• W1489065599 cites W1975931772 @default.
• W1489065599 cites W1986568749 @default.
• W1489065599 cites W2000225649 @default.
• W1489065599 cites W2002132520 @default.
• W1489065599 cites W2014366379 @default.
• W1489065599 cites W2027156218 @default.
• W1489065599 cites W2049413530 @default.
• W1489065599 cites W2087074879 @default.
• W1489065599 cites W2134841682 @default.
• W1489065599 cites W2140172451 @default.
• W1489065599 cites W2156114860 @default.
• W1489065599 cites W2156575905 @default.
• W1489065599 cites W2416667643 @default.
• W1489065599 cites W2738996050 @default.
• W1489065599 doi "https://doi.org/10.3748/wjg.v13.i31.4255" @default.
• W1489065599 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4250627" @default.
• W1489065599 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17696257" @default.
• W1489065599 hasPublicationYear "2007" @default.
• W1489065599 type Work @default.
• W1489065599 sameAs 1489065599 @default.
• W1489065599 citedByCount "26" @default.
• W1489065599 countsByYear W14890655992012 @default.
• W1489065599 countsByYear W14890655992013 @default.
• W1489065599 countsByYear W14890655992014 @default.
• W1489065599 countsByYear W14890655992016 @default.
• W1489065599 countsByYear W14890655992018 @default.
• W1489065599 countsByYear W14890655992019 @default.
• W1489065599 countsByYear W14890655992020 @default.
• W1489065599 countsByYear W14890655992021 @default.
• W1489065599 countsByYear W14890655992023 @default.
• W1489065599 crossrefType "journal-article" @default.
• W1489065599 hasAuthorship W1489065599A5016496299 @default.
• W1489065599 hasAuthorship W1489065599A5043275598 @default.
• W1489065599 hasAuthorship W1489065599A5081075504 @default.
• W1489065599 hasAuthorship W1489065599A5091758507 @default.
• W1489065599 hasBestOaLocation W14890655991 @default.
• W1489065599 hasConcept C104317684 @default.
• W1489065599 hasConcept C121608353 @default.
• W1489065599 hasConcept C12519072 @default.
• W1489065599 hasConcept C127561419 @default.
• W1489065599 hasConcept C153911025 @default.
• W1489065599 hasConcept C185592680 @default.
• W1489065599 hasConcept C190283241 @default.
• W1489065599 hasConcept C2775998712 @default.
• W1489065599 hasConcept C2776415932 @default.
• W1489065599 hasConcept C2777192995 @default.
• W1489065599 hasConcept C2778004101 @default.
• W1489065599 hasConcept C2780295536 @default.
• W1489065599 hasConcept C28859421 @default.
• W1489065599 hasConcept C31573885 @default.
• W1489065599 hasConcept C53009064 @default.
• W1489065599 hasConcept C54355233 @default.
• W1489065599 hasConcept C55493867 @default.
• W1489065599 hasConcept C70899900 @default.
• W1489065599 hasConcept C75385678 @default.
• W1489065599 hasConcept C81885089 @default.
• W1489065599 hasConcept C86803240 @default.
• W1489065599 hasConcept C88634738 @default.
• W1489065599 hasConcept C95444343 @default.
• W1489065599 hasConcept C96232424 @default.
• W1489065599 hasConcept C98274493 @default.
• W1489065599 hasConcept C98424977 @default.
• W1489065599 hasConceptScore W1489065599C104317684 @default.
• W1489065599 hasConceptScore W1489065599C121608353 @default.
• W1489065599 hasConceptScore W1489065599C12519072 @default.
• W1489065599 hasConceptScore W1489065599C127561419 @default.
• W1489065599 hasConceptScore W1489065599C153911025 @default.
• W1489065599 hasConceptScore W1489065599C185592680 @default.
• W1489065599 hasConceptScore W1489065599C190283241 @default.
• W1489065599 hasConceptScore W1489065599C2775998712 @default.
• W1489065599 hasConceptScore W1489065599C2776415932 @default.
• W1489065599 hasConceptScore W1489065599C2777192995 @default.
• W1489065599 hasConceptScore W1489065599C2778004101 @default.
• W1489065599 hasConceptScore W1489065599C2780295536 @default.
• W1489065599 hasConceptScore W1489065599C28859421 @default.
• W1489065599 hasConceptScore W1489065599C31573885 @default.
• W1489065599 hasConceptScore W1489065599C53009064 @default.
• W1489065599 hasConceptScore W1489065599C54355233 @default.
• W1489065599 hasConceptScore W1489065599C55493867 @default.
• W1489065599 hasConceptScore W1489065599C70899900 @default.
• W1489065599 hasConceptScore W1489065599C75385678 @default.
• W1489065599 hasConceptScore W1489065599C81885089 @default.

• next