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- W1489084833 abstract "1467 Objectives 44Ti generates a 3.97 hours half-life 44Sc of high positron branching of 94.3 %. 44Sc may stimulate the application of 44Sc labeled PET radiopharmaceuticals. However, both 44Ti production and 44Ti/44Sc generator design represent challenges for basic radiochemistry. Methods 5 mCi (185 MBq) of 44Ti were obtained via Sc(p,2n) nuclear reaction. In order to design a robust 44Ti/44Sc generator concept, distribution coefficients of Ti (IV) and Sc (III) on both AG 1-X8 (200-400 mesh, Cl--form) and AG 50W-X8 (200-400 mesh, H+-form) resins eluted with HCl and HCl/H2C2O4 solution of various concentrations were investigated systematically. Optimal conditions have been determined for AG 1-X8 resin and mixtures of 0.07 M HCl and 0.005 M H2C2O4 as eluate. Standard elution schemes were compared with a “reverse” type of washing steps after each elution, using 0.07 M HCl / 0.005 M H2C2O4 mixtures. Results A 5 mCi generator was prepared on an anion exchange column (H=150 mm, D=3 mm, V0=0.55 ml). The system achieved elution of 180 MBq 44Sc in 20 ml of eluate solution. The breakthrough of 44Ti is 90 Bq. This corresponds to a separation factor of 2x106. In the context of long-term stability of 44Ti/44Sc generators, a “reverse” type of washing steps after each elution using 0.07 M HCl / 0.005 M H2C2O4 mixtures appeared to be essential. Conclusions After one year of regular elution of a 5 mCi 44Ti/44Sc radionuclide generator, the yield of 44Sc and 44Ti is stable and the breakthrough of 44Ti is very low. The system achieves elution of 97 % (180 MBq) 44Sc in 20 ml of eluate solution. The breakthrough of 44Ti is 5x10-5 % (90 Bq)" @default.
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- W1489084833 date "2010-05-01" @default.
- W1489084833 modified "2023-10-02" @default.
- W1489084833 title "Design and performance of a novel 5 mCi 44T/44Sc-radionuclide generator" @default.
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