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- W1489142574 abstract "Dendritic cells ( DC s) sense the microenvironment through several types of receptors recognizing pathogen‐associated molecular patterns. In particular, C ‐type lectins, expressed by distinct subsets of DC s, recognize and internalize specific carbohydrate antigen in a Ca 2+ ‐dependent manner. Targeting of these receptors is becoming an efficient strategy of delivering antigens in DC ‐based anticancer immunotherapy. Here we investigated the role of the macrophage galactose type C ‐lectin receptor ( MGL ), expressed by immature DC s (iDCs), as a molecular target for α‐N‐acetylgalactosamine ( G al NA c or T n)‐carrying tumor‐associated antigens to improve DC performance. MGL expressed by ex vivo‐generated i DC s from healthy donors was engaged by a 60‐mer MUC 1 9 T n ‐glycopeptide as a T n‐carrying tumor‐associated antigen, and an anti‐ MGL antibody, as a specific MGL binder. We demonstrated that MGL engagement induced homotrimers and homodimers, triggering the phosphorylation of extracellular signal‐regulated kinase 1,2 ( ERK 1,2) and nuclear factor‐κB activation. Analysis of DC phenotype and function demonstrated that MGL engagement improved DC performance as antigen‐presenting cells, promoting the upregulation of maturation markers, a decrease in phagocytosis, an enhancement of motility, and most importantly an increase in antigen‐specific CD 8 + T ‐cell activation. These results demonstrate that the targeting of MGL receptor on human DCs has an adjuvant effect and that this strategy can be used to design novel anticancer vaccines." @default.
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- W1489142574 date "2012-04-01" @default.
- W1489142574 modified "2023-10-16" @default.
- W1489142574 title "Targeting of macrophage galactose‐type <scp>C</scp>‐type lectin (<scp>MGL</scp>) induces <scp>DC</scp> signaling and activation" @default.
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- W1489142574 doi "https://doi.org/10.1002/eji.201142086" @default.
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