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• W1489152021 abstract "Gangliosides, GSLs that contain sialic acid residues, are components of all animal cell membranes. It was first found by Klenk in 1935. He extracted something of new that was called substance X from the brain of a Niemann–Pick disease patient (Klenk, 1939b). In the following years, he understood (Klenk, 1939a) that substance X was a mixture of compounds and he named them “gangliosides”. Gangliosides attracted immediately the interest of many investigators, but in spite of this, progresses in elucidating their structures were slow. In 1947, the structure of sphingosine was elucidated (Carter et al., 1947) and in 1955 that of sialic acid (Gottschalk, 1955). Finally, in 1963, the first ganglioside structure was described (Kuhn and Wiegandt, 1963). Following studies were extensively devoted to fully understand the ganglioside structural complexity, metabolism, cellular topology, biological functions, and pathobiological implications (Macher and Sweeley, 1978; Miller-Podraza et al., 1992; Sandhoff and Christomanou, 1979; Sandhoff and Conzelmann, 1984; Svennerholm et al., 1994). This research is still far to be considered concluded, but today there is a general agreement to consider gangliosides as functional molecules involved in the modulation of tumor metastasis and of cell signaling, cell invasive proliferation, adhesion, and motility (Bassi et al., 1991; Bremer et al., 1984; Caputto et al., 1977; Chan, 1988; Chan, 1989; Davis and Daly, 1980; Facci et al., 1984; Glebov and Nichols, 2004a; Glebov and Nichols, 2004b; Goldenring et al., 1985; Kim et al., 1986; Kreutter et al., 1987; Leon et al., 1981; Lin and Shaw, 2005; Morgan and Seifert, 1979; Partington and Daly, 1979; Roisen et al., 1981; Rybak et al., 1983; Tsuji et al., 1983; Yates et al., 1989). In particular, systematic analysis of ganglioside antigens in various types of cancer was carried out. In these studies, ganglioside changes were observed based on the comparison of tumor tissues with corresponding normal tissues. Dramatic changes of ganglioside composition and metabolism were first shown using a cultured cell population after viral transformation (Hakomori and Murakami, 1968; Mora et al., 1969). In Balb/c 3T3 cells transformed with Kirsten strain of murine sarcoma virus (the tumor is called 3T3KiMSV), asialo-GM2 (Gg3) is greatly accumulated, with deletion of higher gangliosides. Rabbit" @default.
• W1489152021 created "2016-06-24" @default.
• W1489152021 creator A5040899817 @default.
• W1489152021 creator A5050266619 @default.
• W1489152021 creator A5059587343 @default.
• W1489152021 date "2011-06-30" @default.
• W1489152021 modified "2023-10-16" @default.
• W1489152021 title "Changing the Nature of Melanoma Cells by Manipulation of Ganglioside Expression" @default.
• W1489152021 cites W1157574667 @default.
• W1489152021 cites W1466258364 @default.
• W1489152021 cites W1489537116 @default.
• W1489152021 cites W1493713020 @default.
• W1489152021 cites W1502651723 @default.
• W1489152021 cites W1508039723 @default.
• W1489152021 cites W1519595263 @default.
• W1489152021 cites W1524797258 @default.
• W1489152021 cites W1532637157 @default.
• W1489152021 cites W1537880401 @default.
• W1489152021 cites W1544796307 @default.
• W1489152021 cites W1568651320 @default.
• W1489152021 cites W1570778910 @default.
• W1489152021 cites W1574227588 @default.
• W1489152021 cites W1577316626 @default.
• W1489152021 cites W1577838670 @default.
• W1489152021 cites W1578800727 @default.
• W1489152021 cites W1580721471 @default.
• W1489152021 cites W1582104428 @default.
• W1489152021 cites W1582740601 @default.
• W1489152021 cites W1585454125 @default.
• W1489152021 cites W1593097533 @default.
• W1489152021 cites W1625313056 @default.
• W1489152021 cites W1641843888 @default.
• W1489152021 cites W1677469368 @default.
• W1489152021 cites W1938243302 @default.
• W1489152021 cites W1941119820 @default.
• W1489152021 cites W1965615208 @default.
• W1489152021 cites W1968952749 @default.
• W1489152021 cites W1969565707 @default.
• W1489152021 cites W1970358723 @default.
• W1489152021 cites W1971382321 @default.
• W1489152021 cites W1972049323 @default.
• W1489152021 cites W1978688558 @default.
• W1489152021 cites W1981025721 @default.
• W1489152021 cites W1982968895 @default.
• W1489152021 cites W1983987482 @default.
• W1489152021 cites W1984257510 @default.
• W1489152021 cites W1985888795 @default.
• W1489152021 cites W1986593818 @default.
• W1489152021 cites W1989580390 @default.
• W1489152021 cites W1990578192 @default.
• W1489152021 cites W1991593966 @default.
• W1489152021 cites W1992261428 @default.
• W1489152021 cites W1993939182 @default.
• W1489152021 cites W1994360114 @default.
• W1489152021 cites W1994752272 @default.
• W1489152021 cites W1997916071 @default.
• W1489152021 cites W2005343690 @default.
• W1489152021 cites W2006246993 @default.
• W1489152021 cites W2010200252 @default.
• W1489152021 cites W2010304520 @default.
• W1489152021 cites W2011158867 @default.
• W1489152021 cites W2011189175 @default.
• W1489152021 cites W2011717377 @default.
• W1489152021 cites W2015916057 @default.
• W1489152021 cites W2017767253 @default.
• W1489152021 cites W2018072396 @default.
• W1489152021 cites W2019193799 @default.
• W1489152021 cites W2023392228 @default.
• W1489152021 cites W2024161072 @default.
• W1489152021 cites W2026988350 @default.
• W1489152021 cites W2028601165 @default.
• W1489152021 cites W2028757936 @default.
• W1489152021 cites W2029634948 @default.
• W1489152021 cites W2031174583 @default.
• W1489152021 cites W2033178140 @default.
• W1489152021 cites W2033533993 @default.
• W1489152021 cites W2033758838 @default.
• W1489152021 cites W2033961200 @default.
• W1489152021 cites W2038058793 @default.
• W1489152021 cites W2040895383 @default.
• W1489152021 cites W2041985227 @default.
• W1489152021 cites W2043762044 @default.
• W1489152021 cites W2043945964 @default.
• W1489152021 cites W2044505245 @default.
• W1489152021 cites W2047841542 @default.
• W1489152021 cites W2051200797 @default.
• W1489152021 cites W2052667442 @default.
• W1489152021 cites W2054092526 @default.
• W1489152021 cites W2056525230 @default.
• W1489152021 cites W2061335124 @default.
• W1489152021 cites W2061357370 @default.
• W1489152021 cites W2062136146 @default.
• W1489152021 cites W2062573580 @default.
• W1489152021 cites W2063186096 @default.
• W1489152021 cites W2064132257 @default.
• W1489152021 cites W2066505163 @default.
• W1489152021 cites W2066522455 @default.
• W1489152021 cites W2067431096 @default.
• W1489152021 cites W2069444054 @default.
• W1489152021 cites W2069681076 @default.

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